2006•Chemical CommunicationsRequires access

Dry and wet prolines for asymmetric organic solvent-free aldehyde–aldehyde and aldehyde–ketone aldol reactions

Yujiro Hayashi, Seiji Aratake, Takahiko Itoh, Tsubasa Okano, Tatsunobu Sumiya, Mitsuru Shoji

Abstract

Dry and wet prolines were found to catalyze the direct aldol reactions of aldehyde-aldehyde and aldehyde-ketone, respectively, to afford aldols with excellent diastereo- and enantioselectivities, and an organic solvent-free reaction was realized in some cases.

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Key concepts: Aldehyde, Aldol reaction, Ketone, Chemistry, Organic chemistry, Solvent, Aldol condensation, Catalysis