2001•Antimicrobial Agents and ChemotherapyOpen access

Inhibition of Isoniazid-Induced Expression of Mycobacterium tuberculosis Antigen 85 in Sputum: Potential Surrogate Marker in Tuberculosis Chemotherapy Trials

Robert S. Wallis, Manijeh Phillips, John L. Johnson, Luciléia Teixeira, Lia Márcia Massini Canedo Rocha, Ethel Leonor Nóia Maciel, Lynn M. Rose, Charles D. Wells, Moisés Palaci, Reynaldo Dietze, Kathleen D. Eisenach, Jerrold J. Ellner

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Abstract

Mycobacterium tuberculosis antigen 85 is induced in vitro by isoniazid (INH); its sustained induction in sputum during tuberculosis (TB) therapy predicts relapse. In this trial, rifampin or rifalazil inhibited the induction of sputum antigen 85 by INH in a dose-dependent fashion. This approach may facilitate the evaluation of new TB drugs.

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Key concepts: Isoniazid, Sputum, Tuberculosis, Mycobacterium tuberculosis, Medicine, Antigen, Immunology, Chemotherapy