2009•Biology of the NeonateRequires access

Cardiovascular Reactivity of Neonatal and Adult Sheep to Autonomic Stimuli during Adrenergic Depletion

James R. Woods, A Dandavino, Bahij S Nuwayhid, C.R. Brinkman, NICHOLAS S. ASSALI

Abstract

The cardiovascular responses of the neonatal and adult sheep to autonomic agonists and antagonists were studied in the resting state and following adrenergic neuronal depletion with reserpine. Both the neonates and adults showed similar supersensitivity of the effector system of the peripheral circulation to alpha adrenergic stimulation with catecholamines. In addition, the neonates exhibited supersensitivity of the myocardial effector system to beta-adrenergic stimulation. Unusual finding was a marked supersensitivity of the heart and peripheral circulation to cholinergic receptor blockade with atropine, the mechanisms of which are as yet unclear.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Adrenergic, Internal medicine, Endocrinology, Atropine, Stimulation, Reserpine, Medicine, Adrenergic receptor