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2012•Bulletin of the Korean Chemical SocietyOpen access

Precise Size-control of Silica Nanoparticles via Alkoxy Exchange Equilibrium of Tetraethyl Orthosilicate (TEOS) in the Mixed Alcohol Solution

Joohyun Lim, Shin‐Woo Ha, Jin-Kyu Lee

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Abstract

Silica nanoparticles (SNPs) are one of the most interesting materials with regard to their easy preparation, nontoxicity, and simple surface modification. Based on their various advantages, SNPs have been widely studied and used in various fields such as solid support materials in the column chromatography,1 insulating layer and silica-polymer com-posite2 in engineering fields, and bio-imaging and drug/gene delivery systems in nano-biotechnology.3-5 To make SNP work effectively in all these applications, it is necessary to synthesize size-controllable and mono-dispersed silica particles. Since Stöber showed that spherical silica particles having narrow size distribution could be prepared from tetraethyl orthosilicate (TEOS) as silica source in alcohol solvent with water and aqueous ammonia as catalyst,6 his method has been used and modified to prepare mono-

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Silica nanoparticles (SNPs) are one of the most interesting materials with regard to their easy preparation, nontoxicity, and simple surface modification. Based on their various advantages, SNPs have been widely studied and used in various fields such as solid support materials in the column chromatography,1 insulating layer and silica-polymer com-posite2 in engineering fields, and bio-imaging and drug/gene delivery systems in nano-biotechnology.3-5 To make SNP work effectively in all these applications, it is necessary to synthesize size-controllable and mono-dispersed silica particles. Since Stöber showed that spherical silica particles having narrow size distribution could be prepared from tetraethyl orthosilicate (TEOS) as silica source in alcohol solvent with water and aqueous ammonia as catalyst,6 his method has been used and modified to prepare mono-

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Available abstract

Silica nanoparticles (SNPs) are one of the most interesting materials with regard to their easy preparation, nontoxicity, and simple surface modification. Based on their various advantages, SNPs have been widely studied and used in various fields such as solid support materials in the column chromatography,1 insulating layer and silica-polymer com-posite2 in engineering fields, and bio-imaging and drug/gene delivery systems in nano-biotechnology.3-5 To make SNP work effectively in all these applications, it is necessary to synthesize size-controllable and mono-dispersed silica particles. Since Stöber showed that spherical silica particles having narrow size distribution could be prepared from tetraethyl orthosilicate (TEOS) as silica source in alcohol solvent with water and aqueous ammonia as catalyst,6 his method has been used and modified to prepare mono-

Key concepts: Tetraethyl orthosilicate, Orthosilicate, Alkoxy group, Nanoparticle, Alcohol, Chemistry, Chemical engineering, Materials science

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Precise Size-control of Silica Nanoparticles via Alkoxy Exchange Equilibrium of Tetraethyl Orthosilicate (TEOS) in the Mixed Alcohol Solution — Research Paper | ScholarLens