2010•Transactions of the Royal Society of Tropical Medicine and HygieneRequires access

Q fever serology in febrile patients in southeast Iran

Mohammad Khalili, Naser Shahabi-Nejad, Mehdi Golchin

Abstract

There is little information on human Q fever in Iran and other Middle East countries. The aim of this study was to determine apparent Q fever seropositivity among febrile patients with suspected brucellosis in southeast Iran. Coxiella burnetii phases I and II specific IgG antibodies were measured by a commercial enzyme-linked immunosorbent assay (ELISA) in sera from 75 febrile patients. Phase I antibodies were detected in 18 subjects (24%) and phase II antibodies in 27 subjects (36%). This is the first report of human Q fever seropositivity in Iran after 3 decades and demonstrated a high prevalence of C. burnetii exposure in the sampled febrile patients.

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Key concepts: Coxiella burnetii, Serology, Q fever, Brucellosis, Antibody, Medicine, Immunology, Virology