EXHAUSTION

The close accordance of the symptoms of anaphylaxis with those of autointoxication, especially with those of protein intoxications, led to the belief that whatever the intermediate or concurrent effects of the anaphylactic reaction on the system as a whole, the primary cause of the end-results would be found to be identical with that to which we have attributed the end-results of the injection of peptone or other toxic agents, and with other causes of general exhaustion; that is, the belief was that, in their fundamental characteristics, anaphylactic shock and traumatic shock would be found to be identical. The complex chemical pathologic changes which accompany pregnancy with the associated metabolic disturbances make it seem appropriate to include in this section certain studies of pregnant animals. A. HISTOLOGIC STUDIES Injection of Ox Serum. —In two experiments, after the intravenous injection of 2 c.c. of ox serum, all the brain cells were found