2001•Journal of Combinatorial ChemistryRequires access

Development and Application of a Carbonyl-13C-Enriched Backbone Amide Linker for Solid-Phase Reaction Monitoring

Craig J. Jamieson, Miles Congreve, Peter R. Hewitt, Jan J. Scicinski, Steven V. Ley

Abstract

The synthesis and application of a carbonyl-(13)C backbone amide linker are described. The labeled unit is conveniently mixed with commercial resins, providing a rapid means of monitoring chemistry performed with this linker on solid support using conventional (13)C NMR methods.

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Key concepts: Linker, Amide, Solid-phase synthesis, Chemistry, Combinatorial chemistry, Phase (matter), Carbonyl group, Polymer chemistry