2008•Protein and Peptide LettersRequires access
Circular Dichroism Reveals Sensitivity of Glucagon Solution Structure to Fluoroalcohols, pH and Ionic Strength
S. Guest, Vi Nhat Hoang Ngo, Mary Alice Hefford
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Abstract
Circular dichroism reports that glucagon in solution becomes increasingly helical with the addition of fluoroalcohol (which also decreases solution pH), and with changes in pH and ionic strength. Given the variability of structure observed, these data indicate that care must be taken when comparing results obtained under different solution conditions.