2009•ChemBioChemRequires access

Evidence for Pseudoknot Formation of Class I preQ1 Riboswitch Aptamers

Ulrike Rieder, Kathrin Lang, Christoph Kreutz, Norbert Polacek, Ronald Micura

Abstract

All in a knot. The smallest riboswitch forms a pseudoknot in solution. This is demonstrated for preQ(1) class I aptamers by mutational analysis in combination with (1)H NMR-based structure probing. How pseudoknot formation mediates the mRNA response through its expression platform is now open for investigation.

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Key concepts: Pseudoknot, Riboswitch, Aptamer, Computational biology, Knot (papermaking), Chemistry, Biology, Nanotechnology