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2012•Bioorganic & Medicinal Chemistry LettersOpen access

Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates

Christian J. Sund, Oscar Belda, Neera Borkakoti, Jimmy Lindberg, Dean J. Derbyshire, Lotta Vrang, Elizabeth Hamelink, C. Åhgren, Esmeralda A. Woestenenk, Kristina I. Wikstrom, Anders Eneroth, Erik Lindström, Genadiy Kalayanov

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Key concepts: Chemistry, Heteroatom, Stereochemistry, Side chain, Bicyclic molecule, Enzyme, Ring (chemistry), Enzyme inhibitor

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Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates — Research Paper | ScholarLens