Cardioprotective Effects of Lignanoid against Doxorubicin-Induced Oxidative Stress in Rat

This study was aimed to investigate the protective effect of lignanoid against doxorubicin-induced cardiotoxicity in rats. Doxorubicin were administered at the dosage of 5 mg/kg once a week, ip for a period of 5 consecutive weeks. Lignanoid were administered at the dosages of 25, 50 and 100mg/kg, po by gavage for 7 consecutive days in a week for 5 weeks. Lignanoid at the doses of 50 and 100 mg/kg significantly reduced CK-MB, NO and LDH and increased GST levels in the doxorubicin-treated group. Thus, lignanoid ameliorated doxorubicin-induced cardiotoxicity by reducing oxidative stress, abnormal cellular morphology in rat. This study indicates the protective effect of lignanoid against doxorubicin-induced cardiotoxicity.