1989•British Journal of DermatologyRequires access

Anti-SL-Ki antibody in a patient with fatal connective tissue overlap disease

Aurora Parodi, Anna Nigro, Alfredo Rebora

Abstract

A patient with photosensitivity is described who presented with an overlap syndrome combining features of systemic lupus erythematosus with a mild polymyositis and scleroderma and with symptoms of the sicca syndrome. In addition, he was anti-SSA/Ro positive and had a constellation of antibodies directed to ENA including the anti-SL-Ki antibody. The condition was fatal and he died from heart failure and respiratory insufficiency.

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Available abstract

Key concepts: Medicine, Polymyositis, Overlap syndrome, Scleroderma (fungus), Sicca syndrome, Connective tissue disease, Antibody, Dermatomyositis