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Alasmontamine A, A First Tetrakis Monoterpene Indole Alkaloid from Tabernaemontana elegans

Yusuke Hirasawa, Saori Miyama, Takahiro Hosoya, Koichiro Koyama, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Hiroshi Morita

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Abstract

A novel tetrakis monoterpene indole alkaloid, alasmontamine A (1) consisting of bis-vobtusine-type skeletons, was isolated from the leaves of Tabernaemontana elegans. The structure including the relative stereochemistry was elucidated on the basis of spectroscopic data. Alasmontamine A (1) exhibited moderate cell growth inhibitory activity against HL-60 cells.

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What this paper is about

A novel tetrakis monoterpene indole alkaloid, alasmontamine A (1) consisting of bis-vobtusine-type skeletons, was isolated from the leaves of Tabernaemontana elegans. The structure including the relative stereochemistry was elucidated on the basis of spectroscopic data. Alasmontamine A (1) exhibited moderate cell growth inhibitory activity against HL-60 cells.

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Available abstract

A novel tetrakis monoterpene indole alkaloid, alasmontamine A (1) consisting of bis-vobtusine-type skeletons, was isolated from the leaves of Tabernaemontana elegans. The structure including the relative stereochemistry was elucidated on the basis of spectroscopic data. Alasmontamine A (1) exhibited moderate cell growth inhibitory activity against HL-60 cells.

Key concepts: Monoterpene, Apocynaceae, Indole alkaloid, Alkaloid, Chemistry, Indole test, Stereochemistry, Organic chemistry

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