2003•Perspectives on Neurophysiology and Neurogenic Speech and Language DisordersRequires access

Neuroimaging Changes in Preclinical Alzheimer's Disease

Nikki R. Horne, Mark William Bondi

Open publisher page 0 citations

Abstract

No AccessPerspectives on Neurophysiology and Neurogenic Speech and Language DisordersArticle1 Dec 2003Neuroimaging Changes in Preclinical Alzheimer's Disease Nikki R. Horne and Mark W. Bondi Nikki R. Horne San Diego State University/University of California, San Diego University of California, San Diego Google Scholar More articles by this author and Mark W. Bondi VA Medical CenterSan Diego Google Scholar More articles by this author https://doi.org/10.1044/nnsld13.4.12 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In References Albert, M. S., Moss, M. B., Tanzi, R., & Jones, K. (2001). Preclinical prediction of AD using neuropsychological tests.Journal of the International Neuropsychological Society, 7, 631–639. Google Scholar American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders, 4th edition. Washington, DC: American Psychiatric Association Press. Google Scholar Azari, N. P., Pettigrew, K. D., Schapiro, M. R., Haxby, J. V., Grady, C. L., Pietrini, P., Salerno, J. A., Heston, L. L., Rapoport, S. I., Horwitz, B. (1993). Early detection of Alzheimer disease: A statistical approach using positron emission tomographic data.Journal of Cerebral Blood Flow and Metabolism, 13, 438–447. Google Scholar Backman, L., Small, B. J., & Fratiglioni, L. (2001). Stability of the preclinical episodic memory deficit in Alzheimer’s disease.Brain, 124, 96–102. Google Scholar Baron, J. C., Chetelat, G., Desgranges, B., Perchey, G., Landeau, B., de La Sayette, V., & Eustache, F. (2001). In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer’s disease.Neurolmage, 14, 298–309. Google Scholar Bayles, K. A., & Kaszniak, A. W. (1987). Communication and cognition in normal aging and dementia. Boston: College-Hill/Little, Brown and Company. Google Scholar Becker, J. T., Mintum, M. A., Aleva, K., Wiseman, M. B., Nichols, T., & DeKosky, S. T. (1996). Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer’s disease.Neurology, 46, 692–700. Google Scholar Bigler, E. D., Tate, D. F., Miller, M. J., Rice, S. A., Hessel, C. D., Earl, H. D., Tschanz, J. T., Plassman, B., & Welsh-Bohmer, K. A. (2002). Dementia, asymmetry of temporal lobe structures, and apolipo-protein E genotype: Relationships to cerebral atrophy and neu-ropsychological impairment.Journal of the International Neuropsychological Society, 8, 925–933. Google Scholar Bondi, M. W., Monsch, A. U., Galasko, D., Butters, N., Salmon, D. P., & Delis, D. C. (1994). Preclinical cognitive markers of dementia of the Alzheimer type.Neuropsychology, 8, 374–384. Google Scholar Bondi, M. W., Salmon, D. P., Monsch, A. U., Galasko, D., Butters, N., Klauber, M. R., Thai, L. J., & Saitoh, T. (1995). Episodic memory changes are associated with the ApoE-_4 allele in nondemented older adults.Neurology, 45, 2203–2206. Google Scholar Bondi, M. W., Salmon, D. P., Galasko, D., Thomas, R. G., & Thai, L. J. (1999). Neuropsychological function and Apolipoprotein E genotype in the preclinical detection of Alzheimer’s disease.Psychology and Aging, 14, 295–303. Google Scholar Bondi, M. W., Goldin, P., Eyler Zorrilla, L., Lange, K. L., & Brown, G. G. (2002). Novel picture learning in nondemented older adult at genetic risk for Alzheimer’s disease: A functional MRI study.Neurobiology of Aging, 23, S359 (abstract). Google Scholar Bookheimer, S. Y., Strojwas, M. H., Cohen, M. S., Saunders, A. M., Pericak-Vance, M. A., Mazziotta, J. C., & Small, G. W. (2000). Patterns of brain activation in people at risk for Alzheimer’s disease.New England Journal of Medicine, 343, 450–456. Google Scholar Braak, H., & Braak, E. (1991). Neuro-pathological staging of Alzheimer-related changes.Acta Neuropathologica, 82, 239–259. Google Scholar Burggren, A. C., Small, G. W., Sabb, F. W., & Bookheimer, S .Y. (2002). Specificity of brain activation patterns in people at genetic risk for Alzheimer’s disease.American Journal of Geriatric Psychiatry, 10, 44–51. Google Scholar Chen, P., Ratcliff, G., Belle, S. H., Cauley, J. A., DeKosky, S. T., & Ganguli, M. (2001). Patterns of cognitive decline in presymptomatic Alzheimer disease: A prospective community study.Archives of General Psychiatry, 58, 853–858. Google Scholar Delis, D. C., Massman, P. J., Butters, N., Salmon, D. P., Kramer, J. H., & Cermak, L. (1991). Profiles of demented and amnesic patients on the CVLT: Implications for the assessment of memory disorders.Psychological Assessment, 3, 19–26. Google Scholar Desgranges, B., Baron, J.-C., & Eustache, F. (1998). The functional neuroanatomy of episodic memory: The role of the frontal lobes, the hippocampal formation, and other areas.Neurolmage, 8, 198–213. Google Scholar Elias, M., Beiser, A., Wolf, P., Au, R., White, R., & D’Agostino, R. (2000). The preclinical phase of Alzheimer’s disease: A 22-year prospective study of the Framingham cohort.Archives of Neurology, 57, 808–813. Google Scholar Eslinger, P. J., Damasio, A. R., Benton, A. L., & Van Allen, M. (1985). Neuropsychologic detection of abnormal mental decline in older persons.Journal of the American Medical Association, 253, 670–674. Google Scholar Fennema-Notestine, C., Archibald, S. L., Jernigan, T. L., & Thai, L. J. (1997). Quantitative MRI in Alzheimer’s disease and controls with and without the apolipo-protein e4 allele.Abstracts for the Society of Neuroscience, 23, 2173 (abstract). Google Scholar Fox, N. C., Warrington, E. K., Freeborough, P. A., Hartikainen, P., Kennedy, A. M., Stevens, J. M., & Rossor, M. N. (1996). Presymptomatic hippocampal atrophy in Alzheimer’s disease: A longitudinal MRI study.Brain, 119, 2001–2007. Google Scholar Fuld, P. A., Masur, D. M., Blau, A. D., Crystal, H., & Aronson, M. K. (1990). Object-memory evaluation for prospective detection of dementia in normal functioning elderly: Predictive and normative data.Journal of Clinical and Experimental Neuropsychology, 12, 520–528. Google Scholar Garrido, G. E. J., Furuie, S. S., Buchpiguel, C. A., Bottino, C. M. C., Almeida, O. P., Cid, C. G., Camargo, C. H. P., Castro, C. C., Glabus, M. F., & Busatto, G. F. (2002). Relation betweeen medial temporal atrophy and functional brain activity during memory processing in Alzheimer’s disease: a combined MRI and SPECT study.Journal of Neurology, Neurosurgery and Psychiatry, 73, 508–516. Google Scholar Gómez-Isla, T., Price, J. L., McKeel, D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996). Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease.Journal of Neuroscience, 16, 4491–4500. Google Scholar Grober, E., & Kawas, C. (1997). Learning and retention in preclinical and early Alzheimer’s disease.Psychology and Aging, 12, 183–188. Google Scholar Haxby, J. V., Grady, C. L., Duara, R., Schlageter, N., Berg, G., & Rapoport, S. I. (1986). Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer’s-type dementia.Archives of Neurology, 43, 882–885. Google Scholar Henderson, A. S., Easteal, S., Jorm, A. F., Mackinnon, A. J., Korten, A. E., Christensen, H., Croft, L., & Jacomb, P. A. (1995). Apolipoprotein E allele Ε4, dementia, and cognitive decline in a population sample.Lancet, 346, 1387–1390. Google Scholar Howieson, D. B., Dame, A., Camicioli, R., Sexton, G., Payami, H., & Kaye, J. A. (1997). Cognitive markers preceding Alzheimer’s dementia in the healthy oldest old.Journal of the American Geriatrics Society, 45, 584–589. Google Scholar Hyman, B. T., Gomez-Isla, T., Briggs, M., Chung, H., Nichols, S., Kohout, F., & Wallace, R. (1996). Apolipoprotein E and cognitive change in an elderly population.Annals of Neurology, 40, 55–66. Google Scholar Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Waring, S. C., Tangalos, E. G., & Kokmen, E. (1999). Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment.Neurology, 52, 1397–1403. Google Scholar Jack, C. R., Petersen, R. C., Xu, Y., O’Brien, P., Waring, S., Tangalos, E., Smith, G., Ivnik, R., Thibodeau, S., Kokmen, E. (1998). Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer’s disease.Annals of Neurology, 43, 303–310. Google Scholar Jack, C. R., Petersen, R. C., Xu, Y. C., Waring, S. C., O’Brien, P. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., & Kokmen, E. (1997). Medial temporal atrophy on MRI in normal aging and very mild Alzheimer’s disease.Neurology, 49, 786–794. Google Scholar Jacobs, D. M., Sano, M., Dooneief, G., Marder, K., Bell, K. L., & Stern, Y. (1995). Neuropsychological detection and characterization of preclinical Alzheimer’s disease.Neurology, 45, 957–962. Google Scholar Johnson, K. A., Jones, K., Holman, B. L., Becker, J. A., Spiers, P. A., Satlin, A., & Albert, M. S. (1998). Preclinical prediction of Alzheimer’s disease using SPECT.Neurology, 50, 1563–1571. Google Scholar Juottonen, K., Lehtovirta, M., Helisalmi, S., Riekkinen, P. J., & Soininen, H. (1998). Major decrease in the volume of the entorhinal cortex in patients with Alzheimer’s disease carrying the apolipoprotein E_4 allele.Journal of Neurology, Neurosurgery, and Psychiatry, 65, 322–327. Google Scholar Kaszniak, A. W., Wilson, R. S., Fox, J. H., & Stebbins, G. T. (1986). Cognitive assessment in Alzheimer’s disease: Cross-sectional and longitudinal perspectives.Canadian Journal of Neurological Sciences, 12, 420–423. Google Scholar Katzman, R. (1986). Alzheimer’s disease.New England Journal of Medicine, 314, 964–973. Google Scholar Katzman, R., Aronson, M., Fuld, P., Kawas, C, Brown, T., Morgenstern, H., Frishman, W., Gidez, L., Eder, H., & Ooi, W. L. (1989). Development of dementing illness in an 80-year-old volunteer cohort.Annals of Neurology, 25, 317–324. Google Scholar Kawas, C., & Katzman, R. (1999). The epidemiology of dementia and Alzheimer disease.In R. D. Terry, R. Katzman, K. L. Bick, & Sisodica (Eds.), Alzheimer disease (2nd edition). New York: Raven Press. Google Scholar Killiany, R. J., Gomez-Isla, T., Moss, M., Kikinis, R., Sandor, T., Joesz, F., Tanzi, R., Jones, K., Hyman, B. T., & Albert, M. S. (2000). Use of structural magnetic resonance imaging to predict who will get Alzheimer’s disease.Annals of Neurology, 47, 430–439. Google Scholar Killiany, R. J., Hyman, B. T., Gomez-Isla, T., Moss, M. B., Kikinis, R., Jolesz, F., Tanzi, R., Jones, K., & Albert, M. S. (2002). MRI measures of entorhinal cortex vs hippocampus in preclinical AD.Neurology, 58, 1188–1196. Google Scholar Knopman, D. S., DeKosky, S. T., Cummings, J. L., Chui, H., Corey-Bloom, J., Relkin, N., Small, G. W., Miller, B., & Stevens, J. C. (2001). Practice parameter: Diagnosis of dementia (an evidence-based review).Neurology, 56, 1143–1153. Google Scholar Jernigan, T. L.Archibald, S. L., Fennema-Notestine, C., Gamst, A. C., Stout, J. C., Bonner, J., & Hesselink, J. R. (2001). Effects of age on tissues and regions of the cerebrum and cerebellum.Neurobiology of Aging, 22, 581–594. Google Scholar La Rue, A., & Jarvik, L. R. (1980). Reflections of biological changes in the psychological performance of the aged.Age, 3, 29–32. Google Scholar La Rue, A., & Jarvik, L. R. (1987). Cognitive function and prediction of dementia in old age.International Journal of Aging and Human Development, 25, 79–89. Google Scholar La Rue, A., Matsuyama, S. S., McPherson, S., Sherman, J., & Jarvik, L. F. (1992). Cognitive performance in relatives of patients with probable Alzheimer disease: An age at onset effect?.Journal of Clinical and Experimental Neuropsychology, 14, 533–538. Google Scholar Lehtovirta, M., Kuikka, J., Selisalmi, S., Hartikainen, P., Mannermaa, A., Ryynànen, M., Riekkinen, P., & Soininen, H. (1998). Longitudinal SPECT study in Alzheimer’s disease: Relation to apolipoprotein E polymorphism.Journal of Neurology, Neurosurgery, and Psychiatry, 64, 742–746. Google Scholar Lehtovirta, M., Soininen, H., Laasko, M. P., Partanen, K., Helisalmi, S., Mannermaa, A., Ryynànen, M., Kuikka, J., Hartikainen, P., & Riekkinen, P. (1996). SPECT and MRI analysis in Alzheimer’s disease: relation to apolipoprotein E 4 allele.Journal of Neurology, Neurosurgery, and Psychiatry, 60, 644–649. Google Scholar Linn, R. T., Wolf, P. A., Bachman, D. L., Knoefel, J. E., Cobb, J. L., Belanger, A. J., Kaplan, E. F., & D’Agostino, R. B. (1995). The ‘preclinical phase’ of probable Alzheimer’s disease: A 13-year prospective study of the Framingham cohort.Archives of Neurology, 52, 485–490. Google Scholar Masur, D. M., Fuld, P. A., Blau, A. D., Crystal, H., & Aronson, M. K. (1990). Predicting development of dementia in the elderly with the selective reminding test.Journal of Clinical and Experimental Neuropsychology, 12, 529–538. Google Scholar Masur, D. M., Sliwinski, M., Lipton, R. B., Blau, A. D., & Crystal, H. A. (1994). Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons.Neurology, 44, 1427–1432. Google Scholar McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer’s disease: Report of the NINCSD-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease.Neurology, 34, 939–44. Google Scholar Petersen, R. C., Smith, G., Ivnik, R. J., Kokmen, E., & Tangalos, E. G. (1994). Memory function in very early Alzheimer’s disease.Neurology, 44, 867–72. Google Scholar Petersen, R. C., Smith, G., Ivnik, R. J., Tangalos, E. G., Schaid, D. J., Thibodeau, S. N., Kokmen, E., Waring, S. C., & Kurland, L. T. (1995). Apolipoprotein E status as a predictor of the development of Alzheimer’s disease in memory-impaired individuals.Journal of the American Medical Association, 273, 1274–1278. Google Scholar Pietrini, P., Azari, N. P., Grady, C. L., Salerno, J. A., Gonzales-Aviles, A., Heston, L. L., Pettigrew, K. D., Horwitz, B., Haxby, J. V., Schapiro, M. B. (1993). Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer disease: A longitudinal evaluation.Dementia, 4, 94–101. Google Scholar Plassman, B. L., Welsh-Bohmer, K. A., Bigler, E. D.Johnson, S. C., Anderson, C. V., Helms, M. J., Saunders, A. M., & Breitner, J. C. S. (1997). Apolipoprotein E e4 allele and hippocampal volume in twin with normal cognition.Neurology, 48, 985–989. Google Scholar Rao, S. (2002, July). Bridging the divide between neuropsychology and neuroimaging. Invited symposium presented at the 2002 European meeting of the International Neuropsychological Society, Stockholm, Sweden. Google Scholar Reed, T., Carmelli, D., Swan, G. E., Breitner, J. C. S., Welsh, K. A., Jarvik, G. P., Deeb, S., & Auwerx, J. (1994). Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E ε4 allele.Archives of Neurology, 52, 1189–1192. Google Scholar Reiman, E. M., Caselli, R., Alexander, G. E., & Chen, K. (2001). Tracking the decline in cerebral glucose metabolism in persons and laboratory animals at genetic risk for Alzheimer’s disease.Clinical Neuroscience Research, 1, 194–206. Google Scholar Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Tibodeau, S. N., & Osborne, D. (1996). Preclinical evidence of Alzheimer’s disease in persons homozygous for the _4 allele for Apolipoprotein E.The New England Journal of Medicine, 334, 752–758. Google Scholar ReimanE. M., UeckerA., CaselliR. J., LewisS., BandyD., de LeonM. J., De SantiS., ConvitA., OsborneD., WeaverA., & ThibodeauS. N. (1998). Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer’s disease.Annals of Neurology, 44, 288–291. Google Scholar Schmidt, H., Schmidt, R., Fazekas, F., Semmler, J., Kapeller, P., Reinhart, B., & Kostner, G. M. (1996). Apolipoprotein E ε4 allele in the normal elderly: neuro-psychologie and brain MRI correlates.Clinical Genetics, 50, 293–299. Google Scholar Small, G. W., Ercoli, L. M., Silverman, D. H. S., Huang, S.-C., Komo, S., Bookheimer, S. Y., Lavretsky, H., Miller, K., Siddarth, P., Rasgon, N. L., Mazziotta, J. C., Saxena, S., Wu, H. M., Mega, M. S., Cummings, J. L., Saunders, A. M., Pericak-Vance, M. A., Roses, A. D., Barrio, J. R., & Phelps, M. E. (2000). Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer’s disease. Proceedings of the National Academy of Science, 97, 6037–6042. Google Scholar Small, G. W., Mazziotta, J. C., Collins, M. T., Baxter, L. R., Phelps, M. E., Mandelkern, M. A., Kaplan, A., La Rue, A., Adamson, C. F., Chang, L. (1995). Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease.Journal of the American Medical Association, 273, 942–947. Google Scholar Snowdon, D. A., Kemper, S. J., Mortimer, J. A., Greiner, L. H., Wekstein, D. R., & Markesbery, W. R. (1996). Linguistic ability in early life and cognitive function and Alzheimer’s disease in late life. Findings from the Nun Study.Journal of the American Medical Association, 275, 528–532. Google Scholar Soininen, H., Partanen, K., Pitkänen, A., Hallikainen, M., Hänninen, T., Helisalmi, S., Mannermaa, A., Ryynänen, M., Koivisto, K., & Riekkinen, P. (1995). Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E ε4 allele.Neurology, 45, 391–392. Google Scholar Storandt, M., Botwinick, J., Danziger, W. L., Berg, L., & Hughes, C. P. (1984). Psychometric differentiation of mild senile dementia of the Alzheimer type.Archives of Neurology, 42, 497–499. Google Scholar Weiner, M. F., Wighton-Benn, W. H., Risser, R., Svetlik, D., Tintner, R., Horn, J., Rosenberg, R. N., Bonte, F. J. (1993). Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer disease: What is typical?.Journal of Neuropsychiatry and Clinical Neurosciences, 5, 415–418. Google Scholar Welsh, K., Butters, N., Hughes, J., Mohs, R., & Heyman, A. (1991). Detection of abnormal memory decline in mild cases of Alzheimer’s disease using CERAD neuropsychological measures.Archives of Neurology, 48, 278–281. Google Scholar Zonderman, A. B., Giambra, L. M., Arenberg, D., Resnick, S. M., Costa, P. T., & Kawas, C. H. (1995). Changes in immediate visual memory predict cognitive impairment.Archives of Clinical Neuropsychology, 10, 111–123. Google Scholar Additional Resources FiguresReferencesRelatedDetails Volume 13Issue 4December 2003Pages: 12-19 Get Permissions Add to your Mendeley library History Published in issue: Dec 1, 2003 Metrics Topicsasha-topicsasha-article-typesasha-sigsCopyright & Permissions© 2003 American Speech-Language-Hearing AssociationPDF DownloadLoading ...

About this research paper

What this paper is about

No AccessPerspectives on Neurophysiology and Neurogenic Speech and Language DisordersArticle1 Dec 2003Neuroimaging Changes in Preclinical Alzheimer's Disease Nikki R. Horne and Mark W. Bondi Nikki R. Horne San Diego State University/University of California, San Diego University of California, San Diego Google Scholar More articles by this author and Mark W. Bondi VA Medical CenterSan Diego Google Scholar More articles by this author https://doi.org/10.1044/nnsld13.4.12 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In References Albert, M. S., Moss, M. B., Tanzi, R., & Jones, K. (2001). Preclinical prediction of AD using neuropsychological tests.Journal of the International Neuropsychological Society, 7, 631–639. Google Scholar American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders, 4th edition. Washington, DC: American Psychiatric Association Press. Google Scholar Azari, N. P., Pettigrew, K. D., Schapiro, M. R., Haxby, J. V., Grady, C. L., Pietrini, P., Salerno, J. A., Heston, L. L., Rapoport, S. I., Horwitz, B. (1993). Early detection of Alzheimer disease: A statistical approach using positron emission tomographic data.Journal of Cerebral Blood Flow and Metabolism, 13, 438–447. Google Scholar Backman, L., Small, B. J., & Fratiglioni, L. (2001). Stability of the preclinical episodic memory deficit in Alzheimer’s disease.Brain, 124, 96–102. Google Scholar Baron, J. C., Chetelat, G., Desgranges, B., Perchey, G., Landeau, B., de La Sayette, V., & Eustache, F. (2001). In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer’s disease.Neurolmage, 14, 298–309. Google Scholar Bayles, K. A., & Kaszniak, A. W. (1987). Communication and cognition in normal aging and dementia. Boston: College-Hill/Little, Brown and Company. Google Scholar Becker, J. T., Mintum, M. A., Aleva, K., Wiseman, M. B., Nichols, T., & DeKosky, S. T. (1996). Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer’s disease.Neurology, 46, 692–700. Google Scholar Bigler, E. D., Tate, D. F., Miller, M. J., Rice, S. A., Hessel, C. D., Earl, H. D., Tschanz, J. T., Plassman, B., & Welsh-Bohmer, K. A. (2002). Dementia, asymmetry of temporal lobe structures, and apolipo-protein E genotype: Relationships to cerebral atrophy and neu-ropsychological impairment.Journal of the International Neuropsychological Society, 8, 925–933. Google Scholar Bondi, M. W., Monsch, A. U., Galasko, D., Butters, N., Salmon, D. P., & Delis, D. C. (1994). Preclinical cognitive markers of dementia of the Alzheimer type.Neuropsychology, 8, 374–384. Google Scholar Bondi, M. W., Salmon, D. P., Monsch, A. U., Galasko, D., Butters, N., Klauber, M. R., Thai, L. J., & Saitoh, T. (1995). Episodic memory changes are associated with the ApoE-_4 allele in nondemented older adults.Neurology, 45, 2203–2206. Google Scholar Bondi, M. W., Salmon, D. P., Galasko, D., Thomas, R. G., & Thai, L. J. (1999). Neuropsychological function and Apolipoprotein E genotype in the preclinical detection of Alzheimer’s disease.Psychology and Aging, 14, 295–303. Google Scholar Bondi, M. W., Goldin, P., Eyler Zorrilla, L., Lange, K. L., & Brown, G. G. (2002). Novel picture learning in nondemented older adult at genetic risk for Alzheimer’s disease: A functional MRI study.Neurobiology of Aging, 23, S359 (abstract). Google Scholar Bookheimer, S. Y., Strojwas, M. H., Cohen, M. S., Saunders, A. M., Pericak-Vance, M. A., Mazziotta, J. C., & Small, G. W. (2000). Patterns of brain activation in people at risk for Alzheimer’s disease.New England Journal of Medicine, 343, 450–456. Google Scholar Braak, H., & Braak, E. (1991). Neuro-pathological staging of Alzheimer-related changes.Acta Neuropathologica, 82, 239–259. Google Scholar Burggren, A. C., Small, G. W., Sabb, F. W., & Bookheimer, S .Y. (2002). Specificity of brain activation patterns in people at genetic risk for Alzheimer’s disease.American Journal of Geriatric Psychiatry, 10, 44–51. Google Scholar Chen, P., Ratcliff, G., Belle, S. H., Cauley, J. A., DeKosky, S. T., & Ganguli, M. (2001). Patterns of cognitive decline in presymptomatic Alzheimer disease: A prospective community study.Archives of General Psychiatry, 58, 853–858. Google Scholar Delis, D. C., Massman, P. J., Butters, N., Salmon, D. P., Kramer, J. H., & Cermak, L. (1991). Profiles of demented and amnesic patients on the CVLT: Implications for the assessment of memory disorders.Psychological Assessment, 3, 19–26. Google Scholar Desgranges, B., Baron, J.-C., & Eustache, F. (1998). The functional neuroanatomy of episodic memory: The role of the frontal lobes, the hippocampal formation, and other areas.Neurolmage, 8, 198–213. Google Scholar Elias, M., Beiser, A., Wolf, P., Au, R., White, R., & D’Agostino, R. (2000). The preclinical phase of Alzheimer’s disease: A 22-year prospective study of the Framingham cohort.Archives of Neurology, 57, 808–813. Google Scholar Eslinger, P. J., Damasio, A. R., Benton, A. L., & Van Allen, M. (1985). Neuropsychologic detection of abnormal mental decline in older persons.Journal of the American Medical Association, 253, 670–674. Google Scholar Fennema-Notestine, C., Archibald, S. L., Jernigan, T. L., & Thai, L. J. (1997). Quantitative MRI in Alzheimer’s disease and controls with and without the apolipo-protein e4 allele.Abstracts for the Society of Neuroscience, 23, 2173 (abstract). Google Scholar Fox, N. C., Warrington, E. K., Freeborough, P. A., Hartikainen, P., Kennedy, A. M., Stevens, J. M., & Rossor, M. N. (1996). Presymptomatic hippocampal atrophy in Alzheimer’s disease: A longitudinal MRI study.Brain, 119, 2001–2007. Google Scholar Fuld, P. A., Masur, D. M., Blau, A. D., Crystal, H., & Aronson, M. K. (1990). Object-memory evaluation for prospective detection of dementia in normal functioning elderly: Predictive and normative data.Journal of Clinical and Experimental Neuropsychology, 12, 520–528. Google Scholar Garrido, G. E. J., Furuie, S. S., Buchpiguel, C. A., Bottino, C. M. C., Almeida, O. P., Cid, C. G., Camargo, C. H. P., Castro, C. C., Glabus, M. F., & Busatto, G. F. (2002). Relation betweeen medial temporal atrophy and functional brain activity during memory processing in Alzheimer’s disease: a combined MRI and SPECT study.Journal of Neurology, Neurosurgery and Psychiatry, 73, 508–516. Google Scholar Gómez-Isla, T., Price, J. L., McKeel, D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996). Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease.Journal of Neuroscience, 16, 4491–4500. Google Scholar Grober, E., & Kawas, C. (1997). Learning and retention in preclinical and early Alzheimer’s disease.Psychology and Aging, 12, 183–188. Google Scholar Haxby, J. V., Grady, C. L., Duara, R., Schlageter, N., Berg, G., & Rapoport, S. I. (1986). Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer’s-type dementia.Archives of Neurology, 43, 882–885. Google Scholar Henderson, A. S., Easteal, S., Jorm, A. F., Mackinnon, A. J., Korten, A. E., Christensen, H., Croft, L., & Jacomb, P. A. (1995). Apolipoprotein E allele Ε4, dementia, and cognitive decline in a population sample.Lancet, 346, 1387–1390. Google Scholar Howieson, D. B., Dame, A., Camicioli, R., Sexton, G., Payami, H., & Kaye, J. A. (1997). Cognitive markers preceding Alzheimer’s dementia in the healthy oldest old.Journal of the American Geriatrics Society, 45, 584–589. Google Scholar Hyman, B. T., Gomez-Isla, T., Briggs, M., Chung, H., Nichols, S., Kohout, F., & Wallace, R. (1996). Apolipoprotein E and cognitive change in an elderly population.Annals of Neurology, 40, 55–66. Google Scholar Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Waring, S. C., Tangalos, E. G., & Kokmen, E. (1999). Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment.Neurology, 52, 1397–1403. Google Scholar Jack, C. R., Petersen, R. C., Xu, Y., O’Brien, P., Waring, S., Tangalos, E., Smith, G., Ivnik, R., Thibodeau, S., Kokmen, E. (1998). Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer’s disease.Annals of Neurology, 43, 303–310. Google Scholar Jack, C. R., Petersen, R. C., Xu, Y. C., Waring, S. C., O’Brien, P. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., & Kokmen, E. (1997). Medial temporal atrophy on MRI in normal aging and very mild Alzheimer’s disease.Neurology, 49, 786–794. Google Scholar Jacobs, D. M., Sano, M., Dooneief, G., Marder, K., Bell, K. L., & Stern, Y. (1995). Neuropsychological detection and characterization of preclinical Alzheimer’s disease.Neurology, 45, 957–962. Google Scholar Johnson, K. A., Jones, K., Holman, B. L., Becker, J. A., Spiers, P. A., Satlin, A., & Albert, M. S. (1998). Preclinical prediction of Alzheimer’s disease using SPECT.Neurology, 50, 1563–1571. Google Scholar Juottonen, K., Lehtovirta, M., Helisalmi, S., Riekkinen, P. J., & Soininen, H. (1998). Major decrease in the volume of the entorhinal cortex in patients with Alzheimer’s disease carrying the apolipoprotein E_4 allele.Journal of Neurology, Neurosurgery, and Psychiatry, 65, 322–327. Google Scholar Kaszniak, A. W., Wilson, R. S., Fox, J. H., & Stebbins, G. T. (1986). Cognitive assessment in Alzheimer’s disease: Cross-sectional and longitudinal perspectives.Canadian Journal of Neurological Sciences, 12, 420–423. Google Scholar Katzman, R. (1986). Alzheimer’s disease.New England Journal of Medicine, 314, 964–973. Google Scholar Katzman, R., Aronson, M., Fuld, P., Kawas, C, Brown, T., Morgenstern, H., Frishman, W., Gidez, L., Eder, H., & Ooi, W. L. (1989). Development of dementing illness in an 80-year-old volunteer cohort.Annals of Neurology, 25, 317–324. Google Scholar Kawas, C., & Katzman, R. (1999). The epidemiology of dementia and Alzheimer disease.In R. D. Terry, R. Katzman, K. L. Bick, & Sisodica (Eds.), Alzheimer disease (2nd edition). New York: Raven Press. Google Scholar Killiany, R. J., Gomez-Isla, T., Moss, M., Kikinis, R., Sandor, T., Joesz, F., Tanzi, R., Jones, K., Hyman, B. T., & Albert, M. S. (2000). Use of structural magnetic resonance imaging to predict who will get Alzheimer’s disease.Annals of Neurology, 47, 430–439. Google Scholar Killiany, R. J., Hyman, B. T., Gomez-Isla, T., Moss, M. B., Kikinis, R., Jolesz, F., Tanzi, R., Jones, K., & Albert, M. S. (2002). MRI measures of entorhinal cortex vs hippocampus in preclinical AD.Neurology, 58, 1188–1196. Google Scholar Knopman, D. S., DeKosky, S. T., Cummings, J. L., Chui, H., Corey-Bloom, J., Relkin, N., Small, G. W., Miller, B., & Stevens, J. C. (2001). Practice parameter: Diagnosis of dementia (an evidence-based review).Neurology, 56, 1143–1153. Google Scholar Jernigan, T. L.Archibald, S. L., Fennema-Notestine, C., Gamst, A. C., Stout, J. C., Bonner, J., & Hesselink, J. R. (2001). Effects of age on tissues and regions of the cerebrum and cerebellum.Neurobiology of Aging, 22, 581–594. Google Scholar La Rue, A., & Jarvik, L. R. (1980). Reflections of biological changes in the psychological performance of the aged.Age, 3, 29–32. Google Scholar La Rue, A., & Jarvik, L. R. (1987). Cognitive function and prediction of dementia in old age.International Journal of Aging and Human Development, 25, 79–89. Google Scholar La Rue, A., Matsuyama, S. S., McPherson, S., Sherman, J., & Jarvik, L. F. (1992). Cognitive performance in relatives of patients with probable Alzheimer disease: An age at onset effect?.Journal of Clinical and Experimental Neuropsychology, 14, 533–538. Google Scholar Lehtovirta, M., Kuikka, J., Selisalmi, S., Hartikainen, P., Mannermaa, A., Ryynànen, M., Riekkinen, P., & Soininen, H. (1998). Longitudinal SPECT study in Alzheimer’s disease: Relation to apolipoprotein E polymorphism.Journal of Neurology, Neurosurgery, and Psychiatry, 64, 742–746. Google Scholar Lehtovirta, M., Soininen, H., Laasko, M. P., Partanen, K., Helisalmi, S., Mannermaa, A., Ryynànen, M., Kuikka, J., Hartikainen, P., & Riekkinen, P. (1996). SPECT and MRI analysis in Alzheimer’s disease: relation to apolipoprotein E 4 allele.Journal of Neurology, Neurosurgery, and Psychiatry, 60, 644–649. Google Scholar Linn, R. T., Wolf, P. A., Bachman, D. L., Knoefel, J. E., Cobb, J. L., Belanger, A. J., Kaplan, E. F., & D’Agostino, R. B. (1995). The ‘preclinical phase’ of probable Alzheimer’s disease: A 13-year prospective study of the Framingham cohort.Archives of Neurology, 52, 485–490. Google Scholar Masur, D. M., Fuld, P. A., Blau, A. D., Crystal, H., & Aronson, M. K. (1990). Predicting development of dementia in the elderly with the selective reminding test.Journal of Clinical and Experimental Neuropsychology, 12, 529–538. Google Scholar Masur, D. M., Sliwinski, M., Lipton, R. B., Blau, A. D., & Crystal, H. A. (1994). Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons.Neurology, 44, 1427–1432. Google Scholar McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer’s disease: Report of the NINCSD-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease.Neurology, 34, 939–44. Google Scholar Petersen, R. C., Smith, G., Ivnik, R. J., Kokmen, E., & Tangalos, E. G. (1994). Memory function in very early Alzheimer’s disease.Neurology, 44, 867–72. Google Scholar Petersen, R. C., Smith, G., Ivnik, R. J., Tangalos, E. G., Schaid, D. J., Thibodeau, S. N., Kokmen, E., Waring, S. C., & Kurland, L. T. (1995). Apolipoprotein E status as a predictor of the development of Alzheimer’s disease in memory-impaired individuals.Journal of the American Medical Association, 273, 1274–1278. Google Scholar Pietrini, P., Azari, N. P., Grady, C. L., Salerno, J. A., Gonzales-Aviles, A., Heston, L. L., Pettigrew, K. D., Horwitz, B., Haxby, J. V., Schapiro, M. B. (1993). Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer disease: A longitudinal evaluation.Dementia, 4, 94–101. Google Scholar Plassman, B. L., Welsh-Bohmer, K. A., Bigler, E. D.Johnson, S. C., Anderson, C. V., Helms, M. J., Saunders, A. M., & Breitner, J. C. S. (1997). Apolipoprotein E e4 allele and hippocampal volume in twin with normal cognition.Neurology, 48, 985–989. Google Scholar Rao, S. (2002, July). Bridging the divide between neuropsychology and neuroimaging. Invited symposium presented at the 2002 European meeting of the International Neuropsychological Society, Stockholm, Sweden. Google Scholar Reed, T., Carmelli, D., Swan, G. E., Breitner, J. C. S., Welsh, K. A., Jarvik, G. P., Deeb, S., & Auwerx, J. (1994). Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E ε4 allele.Archives of Neurology, 52, 1189–1192. Google Scholar Reiman, E. M., Caselli, R., Alexander, G. E., & Chen, K. (2001). Tracking the decline in cerebral glucose metabolism in persons and laboratory animals at genetic risk for Alzheimer’s disease.Clinical Neuroscience Research, 1, 194–206. Google Scholar Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Tibodeau, S. N., & Osborne, D. (1996). Preclinical evidence of Alzheimer’s disease in persons homozygous for the _4 allele for Apolipoprotein E.The New England Journal of Medicine, 334, 752–758. Google Scholar ReimanE. M., UeckerA., CaselliR. J., LewisS., BandyD., de LeonM. J., De SantiS., ConvitA., OsborneD., WeaverA., & ThibodeauS. N. (1998). Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer’s disease.Annals of Neurology, 44, 288–291. Google Scholar Schmidt, H., Schmidt, R., Fazekas, F., Semmler, J., Kapeller, P., Reinhart, B., & Kostner, G. M. (1996). Apolipoprotein E ε4 allele in the normal elderly: neuro-psychologie and brain MRI correlates.Clinical Genetics, 50, 293–299. Google Scholar Small, G. W., Ercoli, L. M., Silverman, D. H. S., Huang, S.-C., Komo, S., Bookheimer, S. Y., Lavretsky, H., Miller, K., Siddarth, P., Rasgon, N. L., Mazziotta, J. C., Saxena, S., Wu, H. M., Mega, M. S., Cummings, J. L., Saunders, A. M., Pericak-Vance, M. A., Roses, A. D., Barrio, J. R., & Phelps, M. E. (2000). Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer’s disease. Proceedings of the National Academy of Science, 97, 6037–6042. Google Scholar Small, G. W., Mazziotta, J. C., Collins, M. T., Baxter, L. R., Phelps, M. E., Mandelkern, M. A., Kaplan, A., La Rue, A., Adamson, C. F., Chang, L. (1995). Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease.Journal of the American Medical Association, 273, 942–947. Google Scholar Snowdon, D. A., Kemper, S. J., Mortimer, J. A., Greiner, L. H., Wekstein, D. R., & Markesbery, W. R. (1996). Linguistic ability in early life and cognitive function and Alzheimer’s disease in late life. Findings from the Nun Study.Journal of the American Medical Association, 275, 528–532. Google Scholar Soininen, H., Partanen, K., Pitkänen, A., Hallikainen, M., Hänninen, T., Helisalmi, S., Mannermaa, A., Ryynänen, M., Koivisto, K., & Riekkinen, P. (1995). Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E ε4 allele.Neurology, 45, 391–392. Google Scholar Storandt, M., Botwinick, J., Danziger, W. L., Berg, L., & Hughes, C. P. (1984). Psychometric differentiation of mild senile dementia of the Alzheimer type.Archives of Neurology, 42, 497–499. Google Scholar Weiner, M. F., Wighton-Benn, W. H., Risser, R., Svetlik, D., Tintner, R., Horn, J., Rosenberg, R. N., Bonte, F. J. (1993). Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer disease: What is typical?.Journal of Neuropsychiatry and Clinical Neurosciences, 5, 415–418. Google Scholar Welsh, K., Butters, N., Hughes, J., Mohs, R., & Heyman, A. (1991). Detection of abnormal memory decline in mild cases of Alzheimer’s disease using CERAD neuropsychological measures.Archives of Neurology, 48, 278–281. Google Scholar Zonderman, A. B., Giambra, L. M., Arenberg, D., Resnick, S. M., Costa, P. T., & Kawas, C. H. (1995). Changes in immediate visual memory predict cognitive impairment.Archives of Clinical Neuropsychology, 10, 111–123. Google Scholar Additional Resources FiguresReferencesRelatedDetails Volume 13Issue 4December 2003Pages: 12-19 Get Permissions Add to your Mendeley library History Published in issue: Dec 1, 2003 Metrics Topicsasha-topicsasha-article-typesasha-sigsCopyright & Permissions© 2003 American Speech-Language-Hearing AssociationPDF DownloadLoading ...

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

No AccessPerspectives on Neurophysiology and Neurogenic Speech and Language DisordersArticle1 Dec 2003Neuroimaging Changes in Preclinical Alzheimer's Disease Nikki R. Horne and Mark W. Bondi Nikki R. Horne San Diego State University/University of California, San Diego University of California, San Diego Google Scholar More articles by this author and Mark W. Bondi VA Medical CenterSan Diego Google Scholar More articles by this author https://doi.org/10.1044/nnsld13.4.12 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In References Albert, M. S., Moss, M. B., Tanzi, R., & Jones, K. (2001). Preclinical prediction of AD using neuropsychological tests.Journal of the International Neuropsychological Society, 7, 631–639. Google Scholar American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders, 4th edition. Washington, DC: American Psychiatric Association Press. Google Scholar Azari, N. P., Pettigrew, K. D., Schapiro, M. R., Haxby, J. V., Grady, C. L., Pietrini, P., Salerno, J. A., Heston, L. L., Rapoport, S. I., Horwitz, B. (1993). Early detection of Alzheimer disease: A statistical approach using positron emission tomographic data.Journal of Cerebral Blood Flow and Metabolism, 13, 438–447. Google Scholar Backman, L., Small, B. J., & Fratiglioni, L. (2001). Stability of the preclinical episodic memory deficit in Alzheimer’s disease.Brain, 124, 96–102. Google Scholar Baron, J. C., Chetelat, G., Desgranges, B., Perchey, G., Landeau, B., de La Sayette, V., & Eustache, F. (2001). In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer’s disease.Neurolmage, 14, 298–309. Google Scholar Bayles, K. A., & Kaszniak, A. W. (1987). Communication and cognition in normal aging and dementia. Boston: College-Hill/Little, Brown and Company. Google Scholar Becker, J. T., Mintum, M. A., Aleva, K., Wiseman, M. B., Nichols, T., & DeKosky, S. T. (1996). Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer’s disease.Neurology, 46, 692–700. Google Scholar Bigler, E. D., Tate, D. F., Miller, M. J., Rice, S. A., Hessel, C. D., Earl, H. D., Tschanz, J. T., Plassman, B., & Welsh-Bohmer, K. A. (2002). Dementia, asymmetry of temporal lobe structures, and apolipo-protein E genotype: Relationships to cerebral atrophy and neu-ropsychological impairment.Journal of the International Neuropsychological Society, 8, 925–933. Google Scholar Bondi, M. W., Monsch, A. U., Galasko, D., Butters, N., Salmon, D. P., & Delis, D. C. (1994). Preclinical cognitive markers of dementia of the Alzheimer type.Neuropsychology, 8, 374–384. Google Scholar Bondi, M. W., Salmon, D. P., Monsch, A. U., Galasko, D., Butters, N., Klauber, M. R., Thai, L. J., & Saitoh, T. (1995). Episodic memory changes are associated with the ApoE-_4 allele in nondemented older adults.Neurology, 45, 2203–2206. Google Scholar Bondi, M. W., Salmon, D. P., Galasko, D., Thomas, R. G., & Thai, L. J. (1999). Neuropsychological function and Apolipoprotein E genotype in the preclinical detection of Alzheimer’s disease.Psychology and Aging, 14, 295–303. Google Scholar Bondi, M. W., Goldin, P., Eyler Zorrilla, L., Lange, K. L., & Brown, G. G. (2002). Novel picture learning in nondemented older adult at genetic risk for Alzheimer’s disease: A functional MRI study.Neurobiology of Aging, 23, S359 (abstract). Google Scholar Bookheimer, S. Y., Strojwas, M. H., Cohen, M. S., Saunders, A. M., Pericak-Vance, M. A., Mazziotta, J. C., & Small, G. W. (2000). Patterns of brain activation in people at risk for Alzheimer’s disease.New England Journal of Medicine, 343, 450–456. Google Scholar Braak, H., & Braak, E. (1991). Neuro-pathological staging of Alzheimer-related changes.Acta Neuropathologica, 82, 239–259. Google Scholar Burggren, A. C., Small, G. W., Sabb, F. W., & Bookheimer, S .Y. (2002). Specificity of brain activation patterns in people at genetic risk for Alzheimer’s disease.American Journal of Geriatric Psychiatry, 10, 44–51. Google Scholar Chen, P., Ratcliff, G., Belle, S. H., Cauley, J. A., DeKosky, S. T., & Ganguli, M. (2001). Patterns of cognitive decline in presymptomatic Alzheimer disease: A prospective community study.Archives of General Psychiatry, 58, 853–858. Google Scholar Delis, D. C., Massman, P. J., Butters, N., Salmon, D. P., Kramer, J. H., & Cermak, L. (1991). Profiles of demented and amnesic patients on the CVLT: Implications for the assessment of memory disorders.Psychological Assessment, 3, 19–26. Google Scholar Desgranges, B., Baron, J.-C., & Eustache, F. (1998). The functional neuroanatomy of episodic memory: The role of the frontal lobes, the hippocampal formation, and other areas.Neurolmage, 8, 198–213. Google Scholar Elias, M., Beiser, A., Wolf, P., Au, R., White, R., & D’Agostino, R. (2000). The preclinical phase of Alzheimer’s disease: A 22-year prospective study of the Framingham cohort.Archives of Neurology, 57, 808–813. Google Scholar Eslinger, P. J., Damasio, A. R., Benton, A. L., & Van Allen, M. (1985). Neuropsychologic detection of abnormal mental decline in older persons.Journal of the American Medical Association, 253, 670–674. Google Scholar Fennema-Notestine, C., Archibald, S. L., Jernigan, T. L., & Thai, L. J. (1997). Quantitative MRI in Alzheimer’s disease and controls with and without the apolipo-protein e4 allele.Abstracts for the Society of Neuroscience, 23, 2173 (abstract). Google Scholar Fox, N. C., Warrington, E. K., Freeborough, P. A., Hartikainen, P., Kennedy, A. M., Stevens, J. M., & Rossor, M. N. (1996). Presymptomatic hippocampal atrophy in Alzheimer’s disease: A longitudinal MRI study.Brain, 119, 2001–2007. Google Scholar Fuld, P. A., Masur, D. M., Blau, A. D., Crystal, H., & Aronson, M. K. (1990). Object-memory evaluation for prospective detection of dementia in normal functioning elderly: Predictive and normative data.Journal of Clinical and Experimental Neuropsychology, 12, 520–528. Google Scholar Garrido, G. E. J., Furuie, S. S., Buchpiguel, C. A., Bottino, C. M. C., Almeida, O. P., Cid, C. G., Camargo, C. H. P., Castro, C. C., Glabus, M. F., & Busatto, G. F. (2002). Relation betweeen medial temporal atrophy and functional brain activity during memory processing in Alzheimer’s disease: a combined MRI and SPECT study.Journal of Neurology, Neurosurgery and Psychiatry, 73, 508–516. Google Scholar Gómez-Isla, T., Price, J. L., McKeel, D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996). Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease.Journal of Neuroscience, 16, 4491–4500. Google Scholar Grober, E., & Kawas, C. (1997). Learning and retention in preclinical and early Alzheimer’s disease.Psychology and Aging, 12, 183–188. Google Scholar Haxby, J. V., Grady, C. L., Duara, R., Schlageter, N., Berg, G., & Rapoport, S. I. (1986). Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer’s-type dementia.Archives of Neurology, 43, 882–885. Google Scholar Henderson, A. S., Easteal, S., Jorm, A. F., Mackinnon, A. J., Korten, A. E., Christensen, H., Croft, L., & Jacomb, P. A. (1995). Apolipoprotein E allele Ε4, dementia, and cognitive decline in a population sample.Lancet, 346, 1387–1390. Google Scholar Howieson, D. B., Dame, A., Camicioli, R., Sexton, G., Payami, H., & Kaye, J. A. (1997). Cognitive markers preceding Alzheimer’s dementia in the healthy oldest old.Journal of the American Geriatrics Society, 45, 584–589. Google Scholar Hyman, B. T., Gomez-Isla, T., Briggs, M., Chung, H., Nichols, S., Kohout, F., & Wallace, R. (1996). Apolipoprotein E and cognitive change in an elderly population.Annals of Neurology, 40, 55–66. Google Scholar Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Waring, S. C., Tangalos, E. G., & Kokmen, E. (1999). Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment.Neurology, 52, 1397–1403. Google Scholar Jack, C. R., Petersen, R. C., Xu, Y., O’Brien, P., Waring, S., Tangalos, E., Smith, G., Ivnik, R., Thibodeau, S., Kokmen, E. (1998). Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer’s disease.Annals of Neurology, 43, 303–310. Google Scholar Jack, C. R., Petersen, R. C., Xu, Y. C., Waring, S. C., O’Brien, P. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., & Kokmen, E. (1997). Medial temporal atrophy on MRI in normal aging and very mild Alzheimer’s disease.Neurology, 49, 786–794. Google Scholar Jacobs, D. M., Sano, M., Dooneief, G., Marder, K., Bell, K. L., & Stern, Y. (1995). Neuropsychological detection and characterization of preclinical Alzheimer’s disease.Neurology, 45, 957–962. Google Scholar Johnson, K. A., Jones, K., Holman, B. L., Becker, J. A., Spiers, P. A., Satlin, A., & Albert, M. S. (1998). Preclinical prediction of Alzheimer’s disease using SPECT.Neurology, 50, 1563–1571. Google Scholar Juottonen, K., Lehtovirta, M., Helisalmi, S., Riekkinen, P. J., & Soininen, H. (1998). Major decrease in the volume of the entorhinal cortex in patients with Alzheimer’s disease carrying the apolipoprotein E_4 allele.Journal of Neurology, Neurosurgery, and Psychiatry, 65, 322–327. Google Scholar Kaszniak, A. W., Wilson, R. S., Fox, J. H., & Stebbins, G. T. (1986). Cognitive assessment in Alzheimer’s disease: Cross-sectional and longitudinal perspectives.Canadian Journal of Neurological Sciences, 12, 420–423. Google Scholar Katzman, R. (1986). Alzheimer’s disease.New England Journal of Medicine, 314, 964–973. Google Scholar Katzman, R., Aronson, M., Fuld, P., Kawas, C, Brown, T., Morgenstern, H., Frishman, W., Gidez, L., Eder, H., & Ooi, W. L. (1989). Development of dementing illness in an 80-year-old volunteer cohort.Annals of Neurology, 25, 317–324. Google Scholar Kawas, C., & Katzman, R. (1999). The epidemiology of dementia and Alzheimer disease.In R. D. Terry, R. Katzman, K. L. Bick, & Sisodica (Eds.), Alzheimer disease (2nd edition). New York: Raven Press. Google Scholar Killiany, R. J., Gomez-Isla, T., Moss, M., Kikinis, R., Sandor, T., Joesz, F., Tanzi, R., Jones, K., Hyman, B. T., & Albert, M. S. (2000). Use of structural magnetic resonance imaging to predict who will get Alzheimer’s disease.Annals of Neurology, 47, 430–439. Google Scholar Killiany, R. J., Hyman, B. T., Gomez-Isla, T., Moss, M. B., Kikinis, R., Jolesz, F., Tanzi, R., Jones, K., & Albert, M. S. (2002). MRI measures of entorhinal cortex vs hippocampus in preclinical AD.Neurology, 58, 1188–1196. Google Scholar Knopman, D. S., DeKosky, S. T., Cummings, J. L., Chui, H., Corey-Bloom, J., Relkin, N., Small, G. W., Miller, B., & Stevens, J. C. (2001). Practice parameter: Diagnosis of dementia (an evidence-based review).Neurology, 56, 1143–1153. Google Scholar Jernigan, T. L.Archibald, S. L., Fennema-Notestine, C., Gamst, A. C., Stout, J. C., Bonner, J., & Hesselink, J. R. (2001). Effects of age on tissues and regions of the cerebrum and cerebellum.Neurobiology of Aging, 22, 581–594. Google Scholar La Rue, A., & Jarvik, L. R. (1980). Reflections of biological changes in the psychological performance of the aged.Age, 3, 29–32. Google Scholar La Rue, A., & Jarvik, L. R. (1987). Cognitive function and prediction of dementia in old age.International Journal of Aging and Human Development, 25, 79–89. Google Scholar La Rue, A., Matsuyama, S. S., McPherson, S., Sherman, J., & Jarvik, L. F. (1992). Cognitive performance in relatives of patients with probable Alzheimer disease: An age at onset effect?.Journal of Clinical and Experimental Neuropsychology, 14, 533–538. Google Scholar Lehtovirta, M., Kuikka, J., Selisalmi, S., Hartikainen, P., Mannermaa, A., Ryynànen, M., Riekkinen, P., & Soininen, H. (1998). Longitudinal SPECT study in Alzheimer’s disease: Relation to apolipoprotein E polymorphism.Journal of Neurology, Neurosurgery, and Psychiatry, 64, 742–746. Google Scholar Lehtovirta, M., Soininen, H., Laasko, M. P., Partanen, K., Helisalmi, S., Mannermaa, A., Ryynànen, M., Kuikka, J., Hartikainen, P., & Riekkinen, P. (1996). SPECT and MRI analysis in Alzheimer’s disease: relation to apolipoprotein E 4 allele.Journal of Neurology, Neurosurgery, and Psychiatry, 60, 644–649. Google Scholar Linn, R. T., Wolf, P. A., Bachman, D. L., Knoefel, J. E., Cobb, J. L., Belanger, A. J., Kaplan, E. F., & D’Agostino, R. B. (1995). The ‘preclinical phase’ of probable Alzheimer’s disease: A 13-year prospective study of the Framingham cohort.Archives of Neurology, 52, 485–490. Google Scholar Masur, D. M., Fuld, P. A., Blau, A. D., Crystal, H., & Aronson, M. K. (1990). Predicting development of dementia in the elderly with the selective reminding test.Journal of Clinical and Experimental Neuropsychology, 12, 529–538. Google Scholar Masur, D. M., Sliwinski, M., Lipton, R. B., Blau, A. D., & Crystal, H. A. (1994). Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons.Neurology, 44, 1427–1432. Google Scholar McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer’s disease: Report of the NINCSD-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease.Neurology, 34, 939–44. Google Scholar Petersen, R. C., Smith, G., Ivnik, R. J., Kokmen, E., & Tangalos, E. G. (1994). Memory function in very early Alzheimer’s disease.Neurology, 44, 867–72. Google Scholar Petersen, R. C., Smith, G., Ivnik, R. J., Tangalos, E. G., Schaid, D. J., Thibodeau, S. N., Kokmen, E., Waring, S. C., & Kurland, L. T. (1995). Apolipoprotein E status as a predictor of the development of Alzheimer’s disease in memory-impaired individuals.Journal of the American Medical Association, 273, 1274–1278. Google Scholar Pietrini, P., Azari, N. P., Grady, C. L., Salerno, J. A., Gonzales-Aviles, A., Heston, L. L., Pettigrew, K. D., Horwitz, B., Haxby, J. V., Schapiro, M. B. (1993). Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer disease: A longitudinal evaluation.Dementia, 4, 94–101. Google Scholar Plassman, B. L., Welsh-Bohmer, K. A., Bigler, E. D.Johnson, S. C., Anderson, C. V., Helms, M. J., Saunders, A. M., & Breitner, J. C. S. (1997). Apolipoprotein E e4 allele and hippocampal volume in twin with normal cognition.Neurology, 48, 985–989. Google Scholar Rao, S. (2002, July). Bridging the divide between neuropsychology and neuroimaging. Invited symposium presented at the 2002 European meeting of the International Neuropsychological Society, Stockholm, Sweden. Google Scholar Reed, T., Carmelli, D., Swan, G. E., Breitner, J. C. S., Welsh, K. A., Jarvik, G. P., Deeb, S., & Auwerx, J. (1994). Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E ε4 allele.Archives of Neurology, 52, 1189–1192. Google Scholar Reiman, E. M., Caselli, R., Alexander, G. E., & Chen, K. (2001). Tracking the decline in cerebral glucose metabolism in persons and laboratory animals at genetic risk for Alzheimer’s disease.Clinical Neuroscience Research, 1, 194–206. Google Scholar Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Tibodeau, S. N., & Osborne, D. (1996). Preclinical evidence of Alzheimer’s disease in persons homozygous for the _4 allele for Apolipoprotein E.The New England Journal of Medicine, 334, 752–758. Google Scholar ReimanE. M., UeckerA., CaselliR. J., LewisS., BandyD., de LeonM. J., De SantiS., ConvitA., OsborneD., WeaverA., & ThibodeauS. N. (1998). Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer’s disease.Annals of Neurology, 44, 288–291. Google Scholar Schmidt, H., Schmidt, R., Fazekas, F., Semmler, J., Kapeller, P., Reinhart, B., & Kostner, G. M. (1996). Apolipoprotein E ε4 allele in the normal elderly: neuro-psychologie and brain MRI correlates.Clinical Genetics, 50, 293–299. Google Scholar Small, G. W., Ercoli, L. M., Silverman, D. H. S., Huang, S.-C., Komo, S., Bookheimer, S. Y., Lavretsky, H., Miller, K., Siddarth, P., Rasgon, N. L., Mazziotta, J. C., Saxena, S., Wu, H. M., Mega, M. S., Cummings, J. L., Saunders, A. M., Pericak-Vance, M. A., Roses, A. D., Barrio, J. R., & Phelps, M. E. (2000). Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer’s disease. Proceedings of the National Academy of Science, 97, 6037–6042. Google Scholar Small, G. W., Mazziotta, J. C., Collins, M. T., Baxter, L. R., Phelps, M. E., Mandelkern, M. A., Kaplan, A., La Rue, A., Adamson, C. F., Chang, L. (1995). Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease.Journal of the American Medical Association, 273, 942–947. Google Scholar Snowdon, D. A., Kemper, S. J., Mortimer, J. A., Greiner, L. H., Wekstein, D. R., & Markesbery, W. R. (1996). Linguistic ability in early life and cognitive function and Alzheimer’s disease in late life. Findings from the Nun Study.Journal of the American Medical Association, 275, 528–532. Google Scholar Soininen, H., Partanen, K., Pitkänen, A., Hallikainen, M., Hänninen, T., Helisalmi, S., Mannermaa, A., Ryynänen, M., Koivisto, K., & Riekkinen, P. (1995). Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E ε4 allele.Neurology, 45, 391–392. Google Scholar Storandt, M., Botwinick, J., Danziger, W. L., Berg, L., & Hughes, C. P. (1984). Psychometric differentiation of mild senile dementia of the Alzheimer type.Archives of Neurology, 42, 497–499. Google Scholar Weiner, M. F., Wighton-Benn, W. H., Risser, R., Svetlik, D., Tintner, R., Horn, J., Rosenberg, R. N., Bonte, F. J. (1993). Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer disease: What is typical?.Journal of Neuropsychiatry and Clinical Neurosciences, 5, 415–418. Google Scholar Welsh, K., Butters, N., Hughes, J., Mohs, R., & Heyman, A. (1991). Detection of abnormal memory decline in mild cases of Alzheimer’s disease using CERAD neuropsychological measures.Archives of Neurology, 48, 278–281. Google Scholar Zonderman, A. B., Giambra, L. M., Arenberg, D., Resnick, S. M., Costa, P. T., & Kawas, C. H. (1995). Changes in immediate visual memory predict cognitive impairment.Archives of Clinical Neuropsychology, 10, 111–123. Google Scholar Additional Resources FiguresReferencesRelatedDetails Volume 13Issue 4December 2003Pages: 12-19 Get Permissions Add to your Mendeley library History Published in issue: Dec 1, 2003 Metrics Topicsasha-topicsasha-article-typesasha-sigsCopyright & Permissions© 2003 American Speech-Language-Hearing AssociationPDF DownloadLoading ...

Key concepts: Neuropsychology, Medicine, Psychology, Psychiatry, Cognition

Related papers

Back to paper searchBrowse research topicsOriginal source
Neuroimaging Changes in Preclinical Alzheimer's Disease — Research Paper | ScholarLens