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1971•Canadian Journal of Physiology and PharmacologyRequires access

Effect of Phenylephrine on Cardiac Contractility and Adenyl Cyclase Activity

B. G. Benfey, T. Carolin

Open publisher page 40 citations

Abstract

Both phenylephrine and noradrenaline increased the force of contraction of isolated preparations of rabbit and chicken heart. Noradrenaline increased the rate of formation of cyclic 3′,5′-AMP in homogenate of rabbit or chicken heart, but phenylephrine did not. These results demonstrate that sympathomimetic amines can increase cardiac contractility without increasing the activity of adenyl cyclase.

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What this paper is about

Both phenylephrine and noradrenaline increased the force of contraction of isolated preparations of rabbit and chicken heart. Noradrenaline increased the rate of formation of cyclic 3′,5′-AMP in homogenate of rabbit or chicken heart, but phenylephrine did not. These results demonstrate that sympathomimetic amines can increase cardiac contractility without increasing the activity of adenyl cyclase.

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OpenAlex reports 40 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Both phenylephrine and noradrenaline increased the force of contraction of isolated preparations of rabbit and chicken heart. Noradrenaline increased the rate of formation of cyclic 3′,5′-AMP in homogenate of rabbit or chicken heart, but phenylephrine did not. These results demonstrate that sympathomimetic amines can increase cardiac contractility without increasing the activity of adenyl cyclase.

Key concepts: Phenylephrine, Contractility, Contraction (grammar), Internal medicine, Endocrinology, Chemistry, Heart rate, Cyclase

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