2009•International Archives of Allergy and Applied ImmunologyRequires access

Neonatal IgE Injections Do Not Modify Nippostrongylus brasiliensis-lnduced and Mercuric Chloride-Induced IgE Increase in the Rat

P. Manouvriez, François Hirsch, Catherine Sapin, P.-Philippe Druet, Hervé Bazin

Abstract

The effect of neonatal IgE injections on total IgE responses was studied in two rat models. After Nippostrongylus brasiliensis infection, no differences in serum IgE level and surface or cytoplasmic IgE expression were observed between IgE-treated and control LOU/C rats. Likewise, after HgCl2 injection, IgE-treated Brown-Norway rats and controls showed no difference in serum IgE level or in the development of autoimmune glomerulonephritis and proteinuria. It has been concluded that IgE-class-restricted tolerance, induced by neonatal injections of IgE, cannot be observed in rats after strong IgE stimulation.

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Key concepts: Nippostrongylus brasiliensis, Immunoglobulin E, Immunology, Internal medicine, Stimulation, Endocrinology, Chemistry, Medicine