2014•Modern RheumatologyRequires access
Successful tocilizumab therapy in seven patients with refractory adult-onset Still's disease
Ei Bannai, Hiroyuki Yamashita, Shunta Kaneko, Yo Ueda, Takashi Ozaki, Haruka Tsuchiya, Yuko Takahashi, Hiroshi Kaneko, Toshikazu Kano, Akio Mimori
Open publisher page 40 citations
Abstract
To evaluate the effects of tocilizumab (TCZ) on adult-onset Still's disease (AOSD), we reviewed medical records of seven patients with refractory AOSD treated with TCZ at our institution. TCZ therapy might allow rapid corticosteroid tapering and help maintain remission status, that is, resolution of clinical symptoms and normalization of biomarkers such as CRP and ferritin. Patients, however, should be monitored for the development of macrophage activation syndrome when TCZ is administered for active AOSD.