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Novel Phenothiazinium Photosensitizers For Photodynamic Therapy

Louis Cincotta, James W. Foley, Anthony H. Cincotta

Open publisher page 25 citations

Abstract

The replament of the oxygen atom in benzophenoxazines with sulfur leads to the corresponding phenothiazinium ehromophorus The effect that this change, as well as other structural alterations, has on photosensitized singlet oxygen formation partitioning coefficient, and in-vitro phototoxicity is presented. A brief discussion concerning how structural modifications can bring about changes in these parameters is also presented. Preliminary results suggest that some phenothiazines could be promising photosensitizers for photodynamic therapy.

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What this paper is about

The replament of the oxygen atom in benzophenoxazines with sulfur leads to the corresponding phenothiazinium ehromophorus The effect that this change, as well as other structural alterations, has on photosensitized singlet oxygen formation partitioning coefficient, and in-vitro phototoxicity is presented. A brief discussion concerning how structural modifications can bring about changes in these parameters is also presented. Preliminary results suggest that some phenothiazines could be promising photosensitizers for photodynamic therapy.

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Available abstract

The replament of the oxygen atom in benzophenoxazines with sulfur leads to the corresponding phenothiazinium ehromophorus The effect that this change, as well as other structural alterations, has on photosensitized singlet oxygen formation partitioning coefficient, and in-vitro phototoxicity is presented. A brief discussion concerning how structural modifications can bring about changes in these parameters is also presented. Preliminary results suggest that some phenothiazines could be promising photosensitizers for photodynamic therapy.

Key concepts: Phototoxicity, Singlet oxygen, Photodynamic therapy, Photosensitizer, Chemistry, Photochemistry, Oxygen, Combinatorial chemistry

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