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1989•Chinese Journal of Cancer ResearchRequires access

Selective killing of gastric cancer cells by monoclonal antibody conjugated with a chain of ricin

Song Li, Zhang Xueyong, Chen Xitao, Fan Daiming, Tan Lisong, Pan Huizhong, Huang Liqun, GU Yi-qun

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Abstract

A specific cytotoxic agent against gastric cancer was constructed by covalently coupling the ricin A chain to monoclonal artibody, MGb 2 , MGb 2 was modified by SPDP to introduce the 3-(2-pyridylthio) propionyl radical and then treated with a reduced A chain to give a disulfide linked conjugate, that retained the original binding specificity of the antibody moiety. The conjugate obtained retained the activity of the antibody and the biological activity of the A chain well.

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What this paper is about

A specific cytotoxic agent against gastric cancer was constructed by covalently coupling the ricin A chain to monoclonal artibody, MGb 2 , MGb 2 was modified by SPDP to introduce the 3-(2-pyridylthio) propionyl radical and then treated with a reduced A chain to give a disulfide linked conjugate, that retained the original binding specificity of the antibody moiety. The conjugate obtained retained the activity of the antibody and the biological activity of the A chain well.

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Available abstract

A specific cytotoxic agent against gastric cancer was constructed by covalently coupling the ricin A chain to monoclonal artibody, MGb 2 , MGb 2 was modified by SPDP to introduce the 3-(2-pyridylthio) propionyl radical and then treated with a reduced A chain to give a disulfide linked conjugate, that retained the original binding specificity of the antibody moiety. The conjugate obtained retained the activity of the antibody and the biological activity of the A chain well.

Key concepts: Ricin, Conjugate, Monoclonal antibody, Conjugated system, Chemistry, Antibody, Moiety, Immunotoxin

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