2014•Pediatric RheumatologyOpen access

The correlations of serum interleukin-6 (il-6) levels and serum soluble il-6 receptor levels with disease activity in systemic juvenile idiopathic arthritis patients with and without tocilizumab treatment

Butsabong Lerkvaleekul, Sirisucha Soponkanaporn, Soamarat Vilaiyuk

Abstract

Interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) have been demonstrated to play a significant role as inflammatory mediators in systemic juvenile idiopathic arthritis (SJIA). Tocilizumab, a humanized anti-IL-6 receptor antibody, becomes a new biologic treatment for SJIA nowadays but the correlation of serum IL-6 levels and serum sIL-6R levels with disease activity in SJIA with and without tocilizumab treatment are still unclear.

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Available abstract

Key concepts: Tocilizumab, Medicine, Internal medicine, Interleukin 6, Gastroenterology, Rheumatology, Arthritis, Disease