2010•Journal of Liquid Chromatography & Related TechnologiesRequires access

DENSITOMETRIC ANALYSIS OF SELECTED FLUOROQUINOLONES

Katarzyna Bober

Abstract

Fluoroquinolones are the group of very important synthetic drugs, especially in the treatment of urinary tracks infections. The aim of this work was to find the best chromatographic conditions for analysis of ofloxacin and pefloxacin, as well as using the chromatograms for their densitometric analysis in drugs. The calibration curves were prepared for that purpose and the curves were described by mathematic functions. It permitted calculating the contents of fluoroquinolones in drugs investigated. The densitometric scanning was carried out for ofloxacin and pefloxacin. The quite similar values of quantity of spotted and determined ofloxacin and pefloxacin were stated.

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Key concepts: Pefloxacin, Ofloxacin, Chemistry, Chromatography, Densitometry, Calibration curve, Antibacterial agent, Antibiotics