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Irreproducibility of Neutralization of Herpes Simplex Virus under Conditions where Antibody Is Not in Excess

D. Shariff, J. Hallworth, A. Buchan, G. R. B. Skinner

Open publisher page 3 citations

Abstract

Neutralizing activity against herpes simplex virus was significantly reduced if initial virus titers were greater than 10(6) PFU/ml; there was no significant neutralization when initial virus titers approached 10(8) PFU/ml. This was a result of utilization of all available antibody by virus particles and 'free' virus antigen and emphasizes the importance of conducting virus neutralization tests under conditions of antibody excess.

About this research paper

What this paper is about

Neutralizing activity against herpes simplex virus was significantly reduced if initial virus titers were greater than 10(6) PFU/ml; there was no significant neutralization when initial virus titers approached 10(8) PFU/ml. This was a result of utilization of all available antibody by virus particles and 'free' virus antigen and emphasizes the importance of conducting virus neutralization tests under conditions of antibody excess.

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OpenAlex reports 3 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Neutralizing activity against herpes simplex virus was significantly reduced if initial virus titers were greater than 10(6) PFU/ml; there was no significant neutralization when initial virus titers approached 10(8) PFU/ml. This was a result of utilization of all available antibody by virus particles and 'free' virus antigen and emphasizes the importance of conducting virus neutralization tests under conditions of antibody excess.

Key concepts: Neutralization, Herpes simplex virus, Virology, Titer, Virus, Antibody, Neutralizing antibody, Biology

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Irreproducibility of Neutralization of Herpes Simplex Virus under Conditions where Antibody Is Not in Excess — Research Paper | ScholarLens