1986•Journal of GerontologyRequires access

Age-Dependent Changes in the Mechanisms Regulating Dopamine Uptake in the Central Nervous System

Cristina Missale, Stefano Govoni, Giulio Maria Pasinetti, C. Assini, PierFranco Spano, F. Battaini, M. Trabucchi

Abstract

Na+-dependent binding of 3H-Cocaine is located on dopaminergic terminals and is related to the dopamine uptake system. Studies on senescent rats indicate a decrease in 3H-Cocaine binding density in the striatum. In the same tissue an increase in the Km for dopamine uptake is observed. These changes might be relevant in the age-dependent alterations in dopaminergic function.

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Key concepts: Dopaminergic, Dopamine, Striatum, Central nervous system, Neuroscience, Endocrinology, Chemistry, Internal medicine