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Trisomy 12 in B‐cell chronic lymphocytic leultaemia: an evaluation of 33 patients by direct fluorescence in situ hybridization (FISH)

Nicola Bienz, D. L. N. Cardy, M. J. Leyland, M.A. Hultén

Open publisher page 14 citations

Abstract

An adaptation of the standard fluorescence in situ hybridization (FISH) technique allowing rapid analysis (4 h) has been used to study the prevalence of trisomy 12 in 33 patients with B-CLL, of whom 54% have been shown to have this abnormality. The presence of trisomy 12 has been compared with clinical parameters, and there may be a relationship between the prevalence of trisomy 12 in B-CLL and duration of disease.

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What this paper is about

An adaptation of the standard fluorescence in situ hybridization (FISH) technique allowing rapid analysis (4 h) has been used to study the prevalence of trisomy 12 in 33 patients with B-CLL, of whom 54% have been shown to have this abnormality. The presence of trisomy 12 has been compared with clinical parameters, and there may be a relationship between the prevalence of trisomy 12 in B-CLL and duration of disease.

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OpenAlex reports 14 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

An adaptation of the standard fluorescence in situ hybridization (FISH) technique allowing rapid analysis (4 h) has been used to study the prevalence of trisomy 12 in 33 patients with B-CLL, of whom 54% have been shown to have this abnormality. The presence of trisomy 12 has been compared with clinical parameters, and there may be a relationship between the prevalence of trisomy 12 in B-CLL and duration of disease.

Key concepts: Trisomy, Fluorescence in situ hybridization, Fish <Actinopterygii>, In situ hybridization, Chronic lymphocytic leukemia, In situ, Aneuploidy, Biology

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Trisomy 12 in B‐cell chronic lymphocytic leultaemia: an evaluation of 33 patients by direct fluorescence in situ hybridization (FISH) — Research Paper | ScholarLens