1983•Annals of NeurologyRequires access

Lithium interferes with reserpine‐induced dopamine depletion

Avinoam Reches, Mohamed N. Hassan, V. Jackson, Stanley Fahn

Abstract

Long-term lithium treatment attenuated the hypokinetic effect of reserpine in a patient with tardive dyskinesia. In rats, prophylactic lithium administration inhibits reserpine-induced dopamine depletion in the brain. These data indicate that lithium may limit the therapeutic efficacy of reserpine in tardive dyskinesia.

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Key concepts: Reserpine, Tardive dyskinesia, Lithium (medication), Dopamine, Dyskinesia, Tetrabenazine, Pharmacology, Medicine