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Control of Guanylate Cyclase Activity in the Rod Outer Segment

Richard G. Pannbacker

Abstract

Mammalian photoreceptors contain a guanylate cyclase which has a high specific activity and is inhibited by exposure of the rod outer segment to light. Several minutes are required for this inhibition to take effect, indicating that it is not a step in visual excitation. The activity of the enzyme is sensitive to the concentration of calcium ion in the medium, suggesting that light-induced changes in calcium distribution in the photoreceptor could control guanylate cyclase activity.

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Key concepts: GUCY1B3, GUCY1A3, Guanylate cyclase 2C, Guanylate cyclase, GUCY2D, Calcium, Chemistry, Biophysics