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2012•Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIERequires access

Repair of damage and stimulation of growth cone response following laser induced sub-axotomy

Tao T. Wu, Samarendra Kumar Mohanty, Jill Miotke, Ronald L. Meyer, Michael W. Berns

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Abstract

In this paper we induced sub-axotomy axonal damage and repair by use of the laser microbeam in cultured retinal ganglion cells. When growth cones are near the damaged site of an axon, some cases will respond to the damage by extending filopodia towards the damaged axon. In some cases, the filopodia touch the damaged site. These experiments suggest that guidance cues that are sensed by the growth cones are released from the damaged site. These results also indicate that axon growth cone have a role in repair of the neuronal damage.

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What this paper is about

In this paper we induced sub-axotomy axonal damage and repair by use of the laser microbeam in cultured retinal ganglion cells. When growth cones are near the damaged site of an axon, some cases will respond to the damage by extending filopodia towards the damaged axon. In some cases, the filopodia touch the damaged site. These experiments suggest that guidance cues that are sensed by the growth cones are released from the damaged site. These results also indicate that axon growth cone have a role in repair of the neuronal damage.

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Available abstract

In this paper we induced sub-axotomy axonal damage and repair by use of the laser microbeam in cultured retinal ganglion cells. When growth cones are near the damaged site of an axon, some cases will respond to the damage by extending filopodia towards the damaged axon. In some cases, the filopodia touch the damaged site. These experiments suggest that guidance cues that are sensed by the growth cones are released from the damaged site. These results also indicate that axon growth cone have a role in repair of the neuronal damage.

Key concepts: Axotomy, Filopodia, Growth cone, Axon, Microbeam, Neuroscience, Stimulation, Axon guidance

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