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1992•Chemistry LettersRequires access

Temperature Dependent Duplex Formation of 3′-Phosphate Bearing α-2′-Deoxyoctathymidylate Phosphorothioate and Polyriboadenylic Acid Complex

Kazuo Shinozuka, Tsutomu Morita, Hiroaki Sawai

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Abstract

Abstract The temperature dependent duplex formation of α-2′-deoxyoctathymidilate phosphorothioate(α-dTps7Tpo) with polyriboadenylate{poly(rA)} was studied and compared with the duplex formation of the corresponding α-dTpo7Tpo, β-dTpo7Tpo and β-dTps7Tpo with poly(rA). The DNA analog α-dTps7Tpo forms stable duplex with poly(rA) and the duplex exhibited greater stability compared to β-dTps7Tpo and poly(rA) duplex. The obtained results also indicate that the configuration of glycoside bond has greater effect of the stability of duplexes than the modification of internucleotide linkages.

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Abstract The temperature dependent duplex formation of α-2′-deoxyoctathymidilate phosphorothioate(α-dTps7Tpo) with polyriboadenylate{poly(rA)} was studied and compared with the duplex formation of the corresponding α-dTpo7Tpo, β-dTpo7Tpo and β-dTps7Tpo with poly(rA). The DNA analog α-dTps7Tpo forms stable duplex with poly(rA) and the duplex exhibited greater stability compared to β-dTps7Tpo and poly(rA) duplex. The obtained results also indicate that the configuration of glycoside bond has greater effect of the stability of duplexes than the modification of internucleotide linkages.

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Available abstract

Abstract The temperature dependent duplex formation of α-2′-deoxyoctathymidilate phosphorothioate(α-dTps7Tpo) with polyriboadenylate{poly(rA)} was studied and compared with the duplex formation of the corresponding α-dTpo7Tpo, β-dTpo7Tpo and β-dTps7Tpo with poly(rA). The DNA analog α-dTps7Tpo forms stable duplex with poly(rA) and the duplex exhibited greater stability compared to β-dTps7Tpo and poly(rA) duplex. The obtained results also indicate that the configuration of glycoside bond has greater effect of the stability of duplexes than the modification of internucleotide linkages.

Key concepts: Chemistry, Duplex (building), Phosphate, Bearing (navigation), Stereochemistry, Biochemistry, DNA, Cartography

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Temperature Dependent Duplex Formation of 3′-Phosphate Bearing α-2′-Deoxyoctathymidylate Phosphorothioate and Polyriboadenylic Acid Complex — Research Paper | ScholarLens