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Effectiveness of Tranquilizing Drugs in Rats Exposed to Mixed Gamma-Neutron Radiations

Lawrence W. Davis, Thomas A. Strike

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Abstract

Chlorpromazine, triflupromazine, and chlordiazepoxide were studied for their effect on a conditioned avoidance response in rats at selected times following 500-, 1000-, and 10 000-rad whole-body doses of mixed gamma-neutron radiations. The ED50 of the drugs increased in the rats receiving 1000 rads and decreased in those receiving 10 000 rads when compared to unirradiated controls. Although the dose-respone curve may be altered in irradiated rats, the three drugs studied remained effective even after radiation doses associated with central nervous system damage.

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What this paper is about

Chlorpromazine, triflupromazine, and chlordiazepoxide were studied for their effect on a conditioned avoidance response in rats at selected times following 500-, 1000-, and 10 000-rad whole-body doses of mixed gamma-neutron radiations. The ED50 of the drugs increased in the rats receiving 1000 rads and decreased in those receiving 10 000 rads when compared to unirradiated controls. Although the dose-respone curve may be altered in irradiated rats, the three drugs studied remained effective even after radiation doses associated with central nervous system damage.

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Available abstract

Chlorpromazine, triflupromazine, and chlordiazepoxide were studied for their effect on a conditioned avoidance response in rats at selected times following 500-, 1000-, and 10 000-rad whole-body doses of mixed gamma-neutron radiations. The ED50 of the drugs increased in the rats receiving 1000 rads and decreased in those receiving 10 000 rads when compared to unirradiated controls. Although the dose-respone curve may be altered in irradiated rats, the three drugs studied remained effective even after radiation doses associated with central nervous system damage.

Key concepts: Neutron, Radiochemistry, Pharmacology, Gamma ray, Medical physics, Medicine, Toxicology, Nuclear medicine

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