1997•Biomedical ChromatographyRequires access

Direct HPLC separation of ?-aminoester enantiomers on totally synthetic chiral stationary phases

Francesco Gasparrini, Ilaria D’Acquarica, Claudio Villani, Cristina Cimarelli, G. Palmieri

Abstract

The direct separation of beta-aminoester enantiomers by HPLC on synthetic chiral stationary phases based on a pi-acidic derivative of trans 1,2-diaminocyclohexane as selector is described. The application of different columns containing the stationary phase with opposite configurations and in the racemic form to the determination of enantiomeric excess in chemically impure samples is demonstrated.

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Key concepts: Enantiomer, Chemistry, Chiral stationary phase, Chromatography, Stationary phase, High-performance liquid chromatography, Derivative (finance), Chromatographic separation