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2013•Journal of the Saudi Society of Dermatology & Dermatologic SurgeryOpen access

Fatal pyoderma gangrenosum in a patient with inflammatory bowel disease and hypogonadotropic hypogonadism: Case report

Khalid Mohammed Al Attas, Mohammad Kamrul Ahsan, Mohammed A. Buraik, Amr Mohamed Gamal, Hasan Yehia Hannani

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Abstract

Pyoderma gangrenosum is an inflammatory disease that has been found to be associated with many systemic illnesses. Here we describe, first time to our knowledge of pyoderma gangrenosum as well as pyostomatitis vegetans in a patient with hypogonadotropic hypogonadism. Later on inflammatory bowel disease was also detected. The pyoderma lesions appeared as multiple outbreaks which resolved totally after several combined immunosuppressive treatment. The clinical course of pyoderma gangrenosum and inflammatory bowel disease appeared independent, with no apparent overlap in inflammatory activity or response to the drugs administered.

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Pyoderma gangrenosum is an inflammatory disease that has been found to be associated with many systemic illnesses. Here we describe, first time to our knowledge of pyoderma gangrenosum as well as pyostomatitis vegetans in a patient with hypogonadotropic hypogonadism. Later on inflammatory bowel disease was also detected. The pyoderma lesions appeared as multiple outbreaks which resolved totally after several combined immunosuppressive treatment. The clinical course of pyoderma gangrenosum and inflammatory bowel disease appeared independent, with no apparent overlap in inflammatory activity or response to the drugs administered.

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Available abstract

Pyoderma gangrenosum is an inflammatory disease that has been found to be associated with many systemic illnesses. Here we describe, first time to our knowledge of pyoderma gangrenosum as well as pyostomatitis vegetans in a patient with hypogonadotropic hypogonadism. Later on inflammatory bowel disease was also detected. The pyoderma lesions appeared as multiple outbreaks which resolved totally after several combined immunosuppressive treatment. The clinical course of pyoderma gangrenosum and inflammatory bowel disease appeared independent, with no apparent overlap in inflammatory activity or response to the drugs administered.

Key concepts: Pyoderma gangrenosum, Medicine, Inflammatory bowel disease, Pyoderma, Dermatology, Disease, Neutrophilic dermatosis, Hypogonadotropic hypogonadism

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