2010•Nigerian Journal of Pharmaceutical ResearchOpen access

A comparative evaluation of pentazocine and dipyrone on diazepam-induced sleep in mice

JA Anuka, AA Eyitayo, Abdullahi Hamza Yaro, Ben A. Chindo, AM Musa

Abstract

This work reports on the evaluation of pentazocine and dipyrone analgesics on diazepam-induced sleep in mice. Diazepam (10 mg/kg) administered intraperitoneally (ip) was used to determine the onset and duration of sleep in mice and the mean of both set values were calculated and recorded. Pentazocine 20, 30 and 50 mg/kg administered (ip) was found to significantly decrease the onset of diazepam (10 mg/kg) induced sleep dose dependently (P

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Available abstract

Key concepts: Pentazocine, Diazepam, Sleep (system call), Anesthesia, Medicine, Pharmacology, Analgesic, Computer science