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Carbon Tetrachloride Poisoning in Rats: Alteration in Ribosomes of the Liver

Edward A. Smuckler, Earl P. Benditt

Abstract

Microsomes from livers of albino rats treated with carbon tetrachloride were compared with those from normal rats with respect to their ability to incorporate amino acid. Acute carbon tetrachloride poisoning results in depressed capacity of microsomes to incorporate amino acid. From ultracentrifugal data, there is an apparent dissociation of 79S ribosomes into 54S components.

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Key concepts: Carbon tetrachloride, CARBON TETRACHLORIDE POISONING, Microsome, Ribosome, Amino acid, Chemistry, Dissociation (chemistry), Biochemistry