1992Arquivos de Neuro-PsiquiatriaOpen access

Propylthiouracil and peripheral neuropathy

Valentina Van Boekel, José Maurício Godoy, Luiz A. Lamy, Samira Assuf, João Gaspar Corrêa Meyer Neto, Salim Lázaro Balassiano, Luiz E. Prata

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Abstract

Peripheral neuropathy is a rare manifestation in hyperthyroidism. We describe the neurological manifestations of a 38 year old female with Graves' disease who developed peripheral neuropathy in the course of her treatment with propylthiouracil. After the drug was tapered off, the neurological signs disappeared. Therefore, we call attention for a possible toxic effect on peripheral nervous system caused by this drug.

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Peripheral neuropathy is a rare manifestation in hyperthyroidism. We describe the neurological manifestations of a 38 year old female with Graves' disease who developed peripheral neuropathy in the course of her treatment with propylthiouracil. After the drug was tapered off, the neurological signs disappeared. Therefore, we call attention for a possible toxic effect on peripheral nervous system caused by this drug.

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Available abstract

Peripheral neuropathy is a rare manifestation in hyperthyroidism. We describe the neurological manifestations of a 38 year old female with Graves' disease who developed peripheral neuropathy in the course of her treatment with propylthiouracil. After the drug was tapered off, the neurological signs disappeared. Therefore, we call attention for a possible toxic effect on peripheral nervous system caused by this drug.

Key concepts: Propylthiouracil, Peripheral neuropathy, Peripheral, Medicine, Graves' disease, Peripheral nervous system, Antithyroid agent, Drug

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