STUDIES ON VARIATION IN PLASMIN (BLOOD FIBRINOLYSIN) ACTIVITY IN CASES WITH CEREBRAL APOPLECTIC DISEASES

1) In cases with cerebral hemorrhage, blood plasmin activity was elevated within 24 hours after the attack, but it tended to fall after 2 weeks.2) In cases with cerebral infarction, plasmin activity was infrequently elevated even within 24 hours after the attack.3) In cases who died from massive cerevral hemorrhage in a short time, plasmin activation was especially remarkable.4) In cases surviving relatively long after the attack of cerebral hemo-rrhage, plasmin activity showed fluctuation.5) In cases of cerebral hemorrhage taking a favorable turn, plasmin; value was frequently elevated within 24 hours after the attack, but restored to the normal level in about 2 weeks.6) In cases of angiospastic encephalopathy, plasmin value was not elevated at all within 24 hours after the attack.The mechanism of plasmin activation in cerebral apoplexy remains in obscurity in many respects on account of rapid reaction of the plasmin system, complexity of factors concerned, as well as difficulty in their assay, and must be further investigated for the elucidation. However, the results of our present study revealed that there was evident relation between cerebral hemorrhage and plasmin system, and it is considered that they will give important suggestions for the diagnosis, prognosis and treatment of cerebral apoplexy.