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Dynamic changes in serum angiopoietin-1, angiopoietin-2, and angiopoietin-2/angiopoietin-1 ratio in acute myocardial infarction patients treated with primary percutaneous coronary intervention

Shaomin Chen, Lijun Guo, Ming Cui, Lijie Sun, Lin Mi

Abstract

CONTEXT: Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) play divergent roles in myocardial ischemia and reperfusion injury. OBJECTIVE: To investigate serum Ang-1 and Ang-2 levels in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI). METHODS: Serum Ang-1 and Ang-2 were measured in 85 STEMI patients in the first week after PCI. RESULTS: Ang-1, Ang-2 and Ang-2/Ang-1 ratio (Ang-2/1) were all increased at admission, and had dynamic changes after PCI. Ang-2 and Ang-2/1 at admission and 2 h after PCI were positively correlated with peak cardiac troponin T levels. CONCLUSION: The extent of myocardial damage may be linked to circulating Ang-2 and Ang-2/1.

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Key concepts: Angiopoietin 2, Angiopoietin, Medicine, Myocardial infarction, Percutaneous coronary intervention, Angiopoietin receptor, Internal medicine, Cardiology