1986•Drug Development and Industrial PharmacyRequires access

A Note on the Solubility of Progesterone in Aqueous Polyethylene Glycol 400

M. D. Fulford, Joseph E. Slonek, Michael J. Groves

Abstract

The solubility curve of progesterone in aqueous polyethylene glycol (PEG) 400 at ambient room temperature (∼25°C) is bimodal, a break occurring at approximately 60% w/w PEG.It is speculated that the presence of unbound water in the PEG 400/water system depresses the solubility of progesterone in PEG 400 disproportionately.

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Key concepts: Polyethylene glycol, PEG ratio, Solubility, Aqueous solution, PEG 400, Chemistry, Chromatography, Organic chemistry