Intracameral amphotericin B in the management of Candida glabrata anterior uveitis after penetrating keratoplasty

Abstract Purpose To report management of Candida glabrata anterior uveitis after penetrating keratoplasty with intracameral amphotericin B. Methods Case report and literature review Results We report a case of a 79‐year‐old woman that presented with anterior uveitis and a dense endothelial plaque at the graft‐host junction in her only eye six weeks after repeated penetrating keratoplasty with donor tissue that was culture‐positive for Candida glabrata. Anterior chamber tap was performed and 5 µg of amphotericin B was injected in the anterior chamber. Cultures of the anterior chamber were positive for the same pathogen as the corneosleral donor rim. She was also treated with topical 0,5% amphotericin B for the next month and topical corticosteroids. At the end of follow up after 16 months her SCVA was 0,6. There was no evidence of recurrent fungal intraocular infection and the graft remained clear with the endothelial cell density of 2286 cells/mm. Conclusion In our opinion intracameral amphotericin B is effective and safe in the therapy of Candida glabrata anterior uveitis after penetrating keratoplasty.