2001•European Journal of Gastroenterology & HepatologyRequires access

Pathogenesis of portal hypertension

Didier Lebrec, Richard Moreau

Abstract

Portal hypertension is defined by an elevation in portal pressure and is associated with haemodynamic alterations. Haemodynamic changes are characterized by a hyperdynamic circulation in the splanchnic and systemic territories and a reduced pressure effect of vasoconstrictive substances. They were observed in both patients and animals with different types of portal hypertension. In this review, the main results and their mechanisms of the splanchnic and systemic haemodynamic alterations in portal hypertension are discussed.

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Key concepts: Portal hypertension, Medicine, Splanchnic, Hyperdynamic circulation, Splanchnic Circulation, Hemodynamics, Portal venous pressure, Cardiology