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2006•Acta ParasitologicaOpen access

Antiparasitic properties of homoallylamines and related compounds

Alicia Gómez‐Barrio, David Montero-Pereira, Juan José Nogal‐Ruiz, José Antonio Escario, Susana Muelas-Serrano, Vladímir V. Kouznetsov, Leonor Vargas Méndez, Juan Urbina Gonzáles, Carmen Ochoa

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Abstract

Abstract A study of some antiparasitic properties of several homoallylamines and related tetrahydroquinolines and quinolines, previously described, was carried out using in vitro activity assays against the epimastigote form of Trypanosoma cruzi and against Trichomonas vaginalis. Unspecific cytotoxicity against murine macrophages was also studied. Although the antichagasic and trichomonacidal activities are not comparable to those of the standard drugs, nifurtimox and metronidazole, some of the compounds exhibit an interesting specific antiparasitic activity.

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What this paper is about

Abstract A study of some antiparasitic properties of several homoallylamines and related tetrahydroquinolines and quinolines, previously described, was carried out using in vitro activity assays against the epimastigote form of Trypanosoma cruzi and against Trichomonas vaginalis. Unspecific cytotoxicity against murine macrophages was also studied. Although the antichagasic and trichomonacidal activities are not comparable to those of the standard drugs, nifurtimox and metronidazole, some of the compounds exhibit an interesting specific antiparasitic activity.

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Available abstract

Abstract A study of some antiparasitic properties of several homoallylamines and related tetrahydroquinolines and quinolines, previously described, was carried out using in vitro activity assays against the epimastigote form of Trypanosoma cruzi and against Trichomonas vaginalis. Unspecific cytotoxicity against murine macrophages was also studied. Although the antichagasic and trichomonacidal activities are not comparable to those of the standard drugs, nifurtimox and metronidazole, some of the compounds exhibit an interesting specific antiparasitic activity.

Key concepts: Antiparasitic, Nifurtimox, Antiparasitic agent, Biology, Trypanosoma cruzi, Trichomonas vaginalis, Protozoa, Cytotoxicity

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