EFFECT OF ESTRADIOL-17β ON THE METABOLISM OF PHOSPHOLIPIDS AND THEIR PRECURSORS IN RAT UTERUS

The effect of estradiol-17β on the metabolism of phosphatidylethanolamine phosphatidylcholine in rat uterus was investigated in vitro by using 32Porthophosphate, 32P-phosphorylethanolamine, 32P-phosphorylcholine, 32Pphosphatidylethanolamine and 32P-phosphatidylcholine as substrates.1.It was suggested that the biosynthesis of phosphorylethanolamine, phosphorylcholine, phosphatidylethanolamine and phosphatidylcholine was stimulated by estradiol-treatment.2.The incorporation of 32P-phosphorylethanolamine into phosphatidylethanolamine was increased but that of 32P-phosphorylcholine into phosphatidylcholine was not increased by the administration of estradiol-17β.The incorporation of phosphatidylethanolamine into phosphatidylcholine not affected by estradiol-17β and the reaction from phosphatidylcholine phosphatidylethanolamine was not observed.