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1987•British Journal of Clinical PharmacologyOpen access

Inter‐relationship among individual vitamin K‐dependent clotting factors at different levels of anticoagulation.

Elaine Chan, Leon J Aarons, M J Serlin, AM Breckenridge, Malcolm Rowland

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Abstract

1. The effect of subtherapeutic doses of warfarin on the activities of the four vitamin K-dependent clotting factors was studied at steady state in five patients each of whom had completed a therapeutic course of anticoagulation. 2. The four clotting factor activities were shown to be depressed to a similar extent for a given dose of warfarin. 3. The prothrombin complex activity was significantly lower than that of any of the clotting factors.

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1. The effect of subtherapeutic doses of warfarin on the activities of the four vitamin K-dependent clotting factors was studied at steady state in five patients each of whom had completed a therapeutic course of anticoagulation. 2. The four clotting factor activities were shown to be depressed to a similar extent for a given dose of warfarin. 3. The prothrombin complex activity was significantly lower than that of any of the clotting factors.

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Available abstract

1. The effect of subtherapeutic doses of warfarin on the activities of the four vitamin K-dependent clotting factors was studied at steady state in five patients each of whom had completed a therapeutic course of anticoagulation. 2. The four clotting factor activities were shown to be depressed to a similar extent for a given dose of warfarin. 3. The prothrombin complex activity was significantly lower than that of any of the clotting factors.

Key concepts: Warfarin, Clotting factor, Vitamin k, Medicine, Vitamin, Clotting time, Prothrombin complex concentrate, Internal medicine

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Inter‐relationship among individual vitamin K‐dependent clotting factors at different levels of anticoagulation. — Research Paper | ScholarLens