2000Korean Circulation JournalRequires access

Initiation of Torsades de pointes by head-up tilt test in congenital long QT syndrome patient

Ik Soo Jeon, Tae Joon Cha, Kil‐Soo Kim, Dong Wan Kim, Kyu Jong Kim, Seong Man Kim, Seong Jae Joo, Jae‐woo Lee

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Abstract

Long QT syndrome is a cardiac disorder of repolarization which is characterized by electrocardiographic abn- ormalities including prolonged QT interval, T-wave abnormalities and polymorphic ventricular tachycardia known as Torsades de Pointes. Its clinical manifestations are recurrent syncope, seizure, and sudden death. Recently, we experienced Torsades de Pointes (TdP by head-up tilt test in 24 year-old female patient present- ing recurrent syncope and long QT interval. Beta-blocker and left cervicothoracic sympathetic ganglionectomy were not effective, then we tried mexiletine. After mexiletine medication, the QT interval was significantly shortened and there was no more syncope. ( ( ( (Korean Circulation J 2000;30( ( ( (8 :1040-1044

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Long QT syndrome is a cardiac disorder of repolarization which is characterized by electrocardiographic abn- ormalities including prolonged QT interval, T-wave abnormalities and polymorphic ventricular tachycardia known as Torsades de Pointes. Its clinical manifestations are recurrent syncope, seizure, and sudden death. Recently, we experienced Torsades de Pointes (TdP by head-up tilt test in 24 year-old female patient present- ing recurrent syncope and long QT interval. Beta-blocker and left cervicothoracic sympathetic ganglionectomy were not effective, then we tried mexiletine. After mexiletine medication, the QT interval was significantly shortened and there was no more syncope. ( ( ( (Korean Circulation J 2000;30( ( ( (8 :1040-1044

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Available abstract

Long QT syndrome is a cardiac disorder of repolarization which is characterized by electrocardiographic abn- ormalities including prolonged QT interval, T-wave abnormalities and polymorphic ventricular tachycardia known as Torsades de Pointes. Its clinical manifestations are recurrent syncope, seizure, and sudden death. Recently, we experienced Torsades de Pointes (TdP by head-up tilt test in 24 year-old female patient present- ing recurrent syncope and long QT interval. Beta-blocker and left cervicothoracic sympathetic ganglionectomy were not effective, then we tried mexiletine. After mexiletine medication, the QT interval was significantly shortened and there was no more syncope. ( ( ( (Korean Circulation J 2000;30( ( ( (8 :1040-1044

Key concepts: Torsades de pointes, Mexiletine, Medicine, QT interval, Cardiology, Long QT syndrome, Internal medicine, Ventricular tachycardia

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