Initiation of Torsades de pointes by head-up tilt test in congenital long QT syndrome patient
Ik Soo Jeon, Tae Joon Cha, Kil‐Soo Kim, Dong Wan Kim, Kyu Jong Kim, Seong Man Kim, Seong Jae Joo, Jae‐woo Lee
Abstract
Ik Soo Jeon, Tae Joon Cha, Kil‐Soo Kim, Dong Wan Kim, Kyu Jong Kim, Seong Man Kim, Seong Jae Joo, Jae‐woo Lee
Abstract
Long QT syndrome is a cardiac disorder of repolarization which is characterized by electrocardiographic abn- ormalities including prolonged QT interval, T-wave abnormalities and polymorphic ventricular tachycardia known as Torsades de Pointes. Its clinical manifestations are recurrent syncope, seizure, and sudden death. Recently, we experienced Torsades de Pointes (TdP by head-up tilt test in 24 year-old female patient present- ing recurrent syncope and long QT interval. Beta-blocker and left cervicothoracic sympathetic ganglionectomy were not effective, then we tried mexiletine. After mexiletine medication, the QT interval was significantly shortened and there was no more syncope. ( ( ( (Korean Circulation J 2000;30( ( ( (8 :1040-1044
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Long QT syndrome is a cardiac disorder of repolarization which is characterized by electrocardiographic abn- ormalities including prolonged QT interval, T-wave abnormalities and polymorphic ventricular tachycardia known as Torsades de Pointes. Its clinical manifestations are recurrent syncope, seizure, and sudden death. Recently, we experienced Torsades de Pointes (TdP by head-up tilt test in 24 year-old female patient present- ing recurrent syncope and long QT interval. Beta-blocker and left cervicothoracic sympathetic ganglionectomy were not effective, then we tried mexiletine. After mexiletine medication, the QT interval was significantly shortened and there was no more syncope. ( ( ( (Korean Circulation J 2000;30( ( ( (8 :1040-1044
Key concepts: Torsades de pointes, Mexiletine, Medicine, QT interval, Cardiology, Long QT syndrome, Internal medicine, Ventricular tachycardia