1993•The Journal of Clinical PharmacologyRequires access

Nisoldipine: A New Dihydropyridine Calcium‐Channel Blocker

Judith E. Mitchell, William H. Frishman, Mark Heiman

Abstract

Nisoldipine is a new calcium-channel blocker of the dihydropyridine subclass, with a chemical structure similar to nifedipine. It has been used in clinical trials to assess its efficacy and safety in patients with hypertension, angina pectoris, and congestive heart failure. Similar to other dihydropyridines, nisoldipine is a potent peripheral and coronary dilator. The most optimal dosage regimen has not been established in clinical trials. The drug appears to have a favorable side-effect profile.

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Key concepts: Nisoldipine, Dihydropyridine, Nifedipine, Medicine, Calcium channel blocker, Isradipine, Angina, Calcium channel