1980•NeurologyRequires access

Protein binding Of valproic acid in uremic patients

J.F. Bruni, L. H. Wang, Thomas Marbury, C. S. Lee, B. J. Wilder

Abstract

Protein binding of valproic acid was studied in four uremic patients on long-term hemodialysis. Before dialysis, the free fraction was 0.31 +/- 0.11 (SD); this was larger than in nonuremic subjects. During hemodialysis, the free fraction increased significantly (p less than 0.01) in three patients (mean, 0.64 +/- 0.32 SD).

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Key concepts: Valproic Acid, Hemodialysis, Free fraction, Uremia, Dialysis, Internal medicine, Medicine, Endocrinology