Adult-onset Still's Disease in the Etiology of Fever of Unknown Origin and Review of the Literature

Hastal›¤› ve Literatürün ‹rdelenmesi Adult-onset Still's Disease in the Etiology of Fever of Unknown Origin and Review of the Literature Ö Öz ze et t Eriflkin Still hastal›¤› (ESH) etiyoloji ve patogenezi bilinmeyen sistemik inflamatuvar bir hastal›kt›r.Atefl tek ve ana semptom olabilece¤inden nedeni bilinmeyen atefl (NBA) yapan hastal›klar aras›nda önemli bir yer al-maktad›r.Hiperferritinemi, lökositoz varl›¤› ile antinükleer antikor ve romatoid faktör negatifli¤i en önemli laboratuvar bulgular›d›r.Tedavisinde steroid olmayan antiinflamatuvar ilaçlar, kortikosteroidler ve immünmodülator ilaçlar kullan›lmaktad›r.Bu çal›flmada, bafllang›çta NBA olgusu olarak araflt›r›lm›fl ve sonras›nda ESH tan›s› alm›fl olan bir olgu literatür verileri eflli¤inde rapor edilmifltir.Türk Fiz T›p Rehab Derg 2010;56:97-99.A An na ah ht ta ar r K Ke el li im me el le er r: : Nedeni bilinmeyen atefl, eriflkin still hastal›¤›, ferritin, tedavi S Su um mm ma ar ry y Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology and pathogenesis.Since a high fever is often the only manifestation, AOSD is regarded as an important cause of fever of unknown origin (FUO).The most important serological markers are hyperferritinemia, leukocytosis, negative antinuclear antibodies and rheumatoid factor.Nonsteroidal anti-inflammatory drugs, corticosteroids and immunomodulating drugs are used for its treatment.In this study, we present an AOSD case, which was evaluated at the beginning as a FUO, and a review of the related data in the literature.