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2006•Australian and New Zealand Journal of Obstetrics and GynaecologyRequires access

The genetic basis of premature ovarian failure

Kathryn J. Woad, Wendy J. Watkins, Deborah Prendergast, Andrew N. Shelling

Open publisher page 126 citations

Abstract

Premature ovarian failure (POF) is a common condition, affecting approximately 1:100 women. It is characterised by amenorrhea, hypoestrogenism, and elevated gonadotrophin levels in women under the age of 40. It is often an unexpected and distressing diagnosis, which coincides with infertility and menopausal symptoms. There is a well recognised genetic basis to the development of POF. Our laboratory has identified several candidate genes associated with POF.

About this research paper

What this paper is about

Premature ovarian failure (POF) is a common condition, affecting approximately 1:100 women. It is characterised by amenorrhea, hypoestrogenism, and elevated gonadotrophin levels in women under the age of 40. It is often an unexpected and distressing diagnosis, which coincides with infertility and menopausal symptoms. There is a well recognised genetic basis to the development of POF. Our laboratory has identified several candidate genes associated with POF.

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OpenAlex reports 126 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Premature ovarian failure (POF) is a common condition, affecting approximately 1:100 women. It is characterised by amenorrhea, hypoestrogenism, and elevated gonadotrophin levels in women under the age of 40. It is often an unexpected and distressing diagnosis, which coincides with infertility and menopausal symptoms. There is a well recognised genetic basis to the development of POF. Our laboratory has identified several candidate genes associated with POF.

Key concepts: Premature ovarian failure, Hypoestrogenism, Amenorrhea, Infertility, Medicine, Premature Menopause, Gynecology, Menopause

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