The crucial role of osteocyte-derived RANKL in bone homeostasis

1):O5 Epidemiology: Fibromyalgia (FM) is found worldwide, with an estimated prevalence of 1% to 4% of the general population.In Japan epidemiological surveillance showed number of the patient up to1.66% in population-based studies in 2003, following 2.04% by internet surveillance in 2011.3,500 Japanese patients with our FM data base, frequent age of onset is 35 to 55 years, estimated prevalence of FM, reaching 40% in woman of age 30 to 50 years old.FM occurs in children and adolescents, although only a few epidemiologic studies.Pathogenesis: FM was initially one the kind for inflammatory muscle pain.Following this concept FM was classified so called soft-tissue rheumatism.Now FM is recognized CNS sensitization following functional pain caused by neuroendocrine system and stress.The abundant neuroendocrine and pain regulation descending pathway and sensitization of pain receptor target molecules such as α 2 δ ligand, LPA and collapsing response mediator, where currently protein (CRMP) family have been revealed.New diagnosis, provisional ACR 2010 criteria: 1990, ACR proposed FM criteria based on 18 tender point sites on digital palpation with exclusive differential diagnosis.In 2010, provisional criteria is score based on total score of severity for pain and somatic symptom (2010 ACR criteria).Based