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1970•The Journal of Clinical Endocrinology & MetabolismRequires access

Pituitary-Leydig Cell Function in Uremic Males

Jeffrey C. Chen, Donald G. Vidt, Elinor M. Zorn, Marvin C. Hallberg, Ralph G. Wieland

Open publisher page 75 citations

Abstract

Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone and testosterone binding affinity (TBA) were measured in 15 uremic males. The mean control serum testosterone level was 262 ng/100 ml. The testosterone value doubled during acute stimulation with human chorionic gonadotropin (HCG) 4000 U daily, a normal percentage increase. Although LH was significantly elevated, the elevation was inadequate to promote normal Leydig cell function in most instances. This impaired pituitary-Leydig cell mechanism was found in association with a normal TBA. Acute increases in serum testosterone produced by HCG did not alter TBA from control values.

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What this paper is about

Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone and testosterone binding affinity (TBA) were measured in 15 uremic males. The mean control serum testosterone level was 262 ng/100 ml. The testosterone value doubled during acute stimulation with human chorionic gonadotropin (HCG) 4000 U daily, a normal percentage increase. Although LH was significantly elevated, the elevation was inadequate to promote normal Leydig cell function in most instances. This impaired pituitary-Leydig cell mechanism was found in association with a normal TBA. Acute increases in serum testosterone produced by HCG did not alter TBA from control values.

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OpenAlex reports 75 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone and testosterone binding affinity (TBA) were measured in 15 uremic males. The mean control serum testosterone level was 262 ng/100 ml. The testosterone value doubled during acute stimulation with human chorionic gonadotropin (HCG) 4000 U daily, a normal percentage increase. Although LH was significantly elevated, the elevation was inadequate to promote normal Leydig cell function in most instances. This impaired pituitary-Leydig cell mechanism was found in association with a normal TBA. Acute increases in serum testosterone produced by HCG did not alter TBA from control values.

Key concepts: Internal medicine, Endocrinology, Leydig cell, Testosterone (patch), Luteinizing hormone, Human chorionic gonadotropin, Follicle-stimulating hormone, Gonadotropin

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