2011•Chemical CommunicationsRequires access

X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG)

Marta Ferraroni, Carla Bazzicalupi, Anna Rita Bilia, Paola Gratteri

Abstract

The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)(2) DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two "two-molecules" DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)(2) DNA in its iminium form.

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Key concepts: Isoquinoline, Sanguinarine, Berberine, Chemistry, DNA, Stereochemistry, Alkaloid, Crystallography